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https://hdl.handle.net/2440/49015
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dc.contributor.author | Hader, T. | - |
dc.contributor.author | Wainwright, D. | - |
dc.contributor.author | Shandala, T. | - |
dc.contributor.author | Saint, R. | - |
dc.contributor.author | Taubert, H. | - |
dc.contributor.author | Bronner, G. | - |
dc.contributor.author | Jackle, H. | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | Current Biology, 2000; 10(1):51-54 | - |
dc.identifier.issn | 0960-9822 | - |
dc.identifier.issn | 1879-0445 | - |
dc.identifier.uri | http://hdl.handle.net/2440/49015 | - |
dc.description.abstract | Transcriptional control of the Drosophila terminal gap gene huckebein (hkb) depends on Torso (Tor) receptor tyrosine kinase (RTK) signaling and the Rel/NFB homolog Dorsal (Dl) . Dl acts as an intrinsic transcriptional activator in the ventral region of the embryo, but under certain conditions, such as when it is associated with the non-DNA-binding co-repressor Groucho (Gro), it is converted into a repressor . Gro is recruited to the enhancer element in the vicinity of Dl by sequence-specific transcription factors such as Dead Ringer (Dri) . We examined the interplay between Dl, Gro and Dri on the hkb enhancer and show that when acting over a distance, Gro abolishes rather than converts Dl activator function. Reducing the distance between Dl- and Dri-binding sites, however, switches Dl into a Gro-dependent repressor that overrides activation of transcription. Both of the distance-dependent regulatory options of Gro - quenching and silencing of transcription- are inhibited by RTK signaling. These data describe a newly identified mode of function for Gro when acting in concert with Dl. RTK signaling provides a way of modulating Dl function by interfering either with Gro activity or with Dri-dependent recruitment of Gro to the enhancer. | - |
dc.description.statementofresponsibility | Häder T, Wainwright D, Shandala T, Saint R, Taubert H, Brönner G and Jäckle H. | - |
dc.language.iso | en | - |
dc.publisher | Dell Press | - |
dc.source.uri | http://dx.doi.org/10.1016/s0960-9822(99)00265-1 | - |
dc.subject | Mesoderm | - |
dc.subject | Animals | - |
dc.subject | Animals, Genetically Modified | - |
dc.subject | Drosophila melanogaster | - |
dc.subject | Receptor Protein-Tyrosine Kinases | - |
dc.subject | DNA-Binding Proteins | - |
dc.subject | Insect Proteins | - |
dc.subject | Drosophila Proteins | - |
dc.subject | Nuclear Proteins | - |
dc.subject | Phosphoproteins | - |
dc.subject | Recombinant Fusion Proteins | - |
dc.subject | Transcription Factors | - |
dc.subject | Repressor Proteins | - |
dc.subject | Mutagenesis, Site-Directed | - |
dc.subject | Signal Transduction | - |
dc.subject | Transcription, Genetic | - |
dc.subject | Gene Expression Regulation, Developmental | - |
dc.subject | Gene Silencing | - |
dc.subject | Sequence Deletion | - |
dc.subject | Base Sequence | - |
dc.subject | Regulatory Sequences, Nucleic Acid | - |
dc.subject | Morphogenesis | - |
dc.subject | Molecular Sequence Data | - |
dc.subject | Basic Helix-Loop-Helix Transcription Factors | - |
dc.title | Receptor tyrosine kinase signaling regulates different modes of Groucho-dependent control of Dorsal | - |
dc.type | Journal article | - |
dc.contributor.organisation | Centre for the Molecular Genetics of Development | - |
dc.identifier.doi | 10.1016/S0960-9822(99)00265-1 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest Centre for the Molecular Genetics of Development publications Molecular and Biomedical Science publications |
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