Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/50006
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Type: Journal article
Title: In vitro Maturation of Mammalian oocytes: outcomes and consequences
Author: Banwell, K.
Thompson, J.
Citation: Seminars in Reproductive Medicine, 2008; 26(2):162-174
Publisher: Thieme Medical Publ Inc
Issue Date: 2008
ISSN: 1526-8004
1526-4564
Organisation: Research Centre for Reproductive Health
Statement of
Responsibility: 
Kelly M. Banwell and Jeremy G. Thompson
Abstract: The application of in vitro maturation (IVM) of oocytes as a technology to assist animal production and clinical infertility treatment remains poor because of the reduced developmental competence of oocytes after IVM, despite several decades of research. Reduced meiotic maturation rates, fertilization rates, and blastocyst production reveal short-term developmental insufficiency of oocytes when compared with in vivo-matured counterparts. However, there is an increasing body of evidence that demonstrates the capacity of IVM efficiency to be improved, some of which is reviewed here. Of more concern is the role that IVM of oocytes may play in causing or accentuating long-term development and health of fetuses and neonates after in vitro production of embryos and embryo transfer. This is a largely unexplored area, yet the application of such techniques, especially the safety of clinical IVM, is significant and requires monitoring before acceptance as a routine procedure.
Keywords: oocyte; maturation; IVM; mammals; mouse
Description: Copyright © 2008 Thieme Medical Publishers
RMID: 0020080304
DOI: 10.1055/s-2008-1042955
Appears in Collections:Obstetrics and Gynaecology publications

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