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https://hdl.handle.net/2440/50664
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Type: | Journal article |
Title: | Selective modulation of intracortical inhibition by low-intensity Theta Burst Stimulation |
Author: | McAllister, S. Rothwell, J. Ridding, M. |
Citation: | Clinical Neurophysiology, 2009; 120(4):820-826 |
Publisher: | Elsevier Sci Ireland Ltd |
Issue Date: | 2009 |
ISSN: | 1388-2457 1872-8952 |
Statement of Responsibility: | S.M. McAllister, J.C. Rothwell and M.C. Ridding |
Abstract: | <h4>Objective</h4>Theta Burst Stimulation (TBS) is a repetitive transcranial magnetic stimulation paradigm which has effects on both excitatory and inhibitory intracortical pathways when applied at an intensity of 80% of active motor threshold. As intracortical inhibitory pathways have a lower threshold for activation than excitatory pathways, we sought to determine whether it was possible to selectively target cortical inhibitory circuitry by reducing the intensity of TBS to 70% of active motor threshold.<h4>Methods</h4>Motor evoked potentials (MEPs), short latency intracortical facilitation (SICF), intracortical facilitation (ICF) and short interval intracortical inhibition (SICI) were measured at baseline, 5-20 and 20-35 min following continuous (cTBS) and intermittent (iTBS) low-intensity TBS in nine healthy subjects.<h4>Results</h4>Low-intensity cTBS significantly reduced SICI 5-20 min following stimulation, whilst having no effect on MEPs, SICF or ICF. Low-intensity iTBS had no effect on SICI, MEPs, SICF or ICF.<h4>Conclusions</h4>It is possible to selectively target intracortical inhibitory networks for modulation by low-intensity TBS, however, responses may critically depend upon the particular paradigm chosen.<h4>Significance</h4>These findings have important implications for the treatment of neurological disorders where abnormal levels of intracortical inhibition are present, such as Parkinson's disease and focal hand dystonia and requires further investigation. |
Keywords: | Muscle, Skeletal Pyramidal Tracts Nerve Net Humans Electromyography Analysis of Variance Cross-Over Studies Electric Stimulation Reaction Time Evoked Potentials, Motor Neural Inhibition Time Factors Adolescent Adult Female Male Transcranial Magnetic Stimulation Biophysical Phenomena Young Adult |
Description: | Copyright © 2009 International Federation of Clinical Neurophysiology Published by Elsevier Ireland Ltd. |
DOI: | 10.1016/j.clinph.2009.02.003 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/601528/description#description |
Published version: | http://dx.doi.org/10.1016/j.clinph.2009.02.003 |
Appears in Collections: | Aurora harvest 5 Molecular and Biomedical Science publications |
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