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https://hdl.handle.net/2440/51168
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dc.contributor.author | Blyth, C. | - |
dc.contributor.author | Best, E. | - |
dc.contributor.author | Jones, C. | - |
dc.contributor.author | Nourse, C. | - |
dc.contributor.author | Goldwater, P. | - |
dc.contributor.author | Daley, A. | - |
dc.contributor.author | Burgner, D. | - |
dc.contributor.author | Henry, G. | - |
dc.contributor.author | Palasanthiran, P. | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | The Pediatric Infectious Disease Journal, 2009; 28(9):801-805 | - |
dc.identifier.issn | 0891-3668 | - |
dc.identifier.issn | 1532-0987 | - |
dc.identifier.uri | http://hdl.handle.net/2440/51168 | - |
dc.description | © 2009 Lippincott Williams & Wilkins, Inc. | - |
dc.description.abstract | Background: The epidemiology and management of nontuberculous mycobacterial (NTM) infection in Australian children is unknown. Methods: From July 2004 to June 2007, clinicians identified children with NTM infection as part of a nationwide active surveillance network. Following notification, detailed data were collected. Results: From 192 reports, data were received on 153 cases (response rate: 79.7%). Of these, 102 met inclusion criteria. The median age was 2.9 years. Predisposing conditions were infrequent and included chronic respiratory disease (n = 12) and immunosuppression (n = 6). Lymphadenitis was the most frequent presentation (n = 68) with pulmonary and disseminated disease infrequent (n = 14 and 3, respectively). NTM was isolated in 68 cases with Mycobacterium avium-intracellulare complex most frequently isolated (33/68; 48.5%). Surgery was performed in 78 cases and 42 children were treated with antimycobacterial therapy. Twenty-five subjects received surgery and antimycobacterial therapy. Follow-up data were available for 77 children with recurrence observed in 18 cases. Complete excision was associated with a higher rate of treatment success when compared with all other therapies (OR: 9.48 [95% CI: 2.00-44.97], P = 0.001). Mycobacterium lentiflavum infection accounted for 4.4% of culture confirmed cases and had a lower rate of treatment success than other species (0% vs. 78.2%; P = 0.016). Conclusions: The incidence of NTM infection in Australian children is 0.84 of 100,000 (95% CI: 0.68-1.02). Infection occurs most often in young children without predisposing conditions. Despite therapy, there was recurrence in 23.4% of cases. | - |
dc.description.statementofresponsibility | Blyth Christopher C., Best Emma J., Jones Cheryl A., Nourse Clare, Goldwater Paul N., Daley Andrew J., Burgner David, Henry Guy and Palasanthiran Pamela | - |
dc.language.iso | en | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.source.uri | http://dx.doi.org/10.1097/inf.0b013e31819f7b3f | - |
dc.subject | Humans | - |
dc.subject | Mycobacterium | - |
dc.subject | Mycobacterium Infections | - |
dc.subject | Recurrence | - |
dc.subject | Antitubercular Agents | - |
dc.subject | Treatment Outcome | - |
dc.subject | Incidence | - |
dc.subject | Age Factors | - |
dc.subject | Adolescent | - |
dc.subject | Child | - |
dc.subject | Child, Preschool | - |
dc.subject | Infant | - |
dc.subject | Australia | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.title | Nontuberculous mycobacterial infection in children A prospective national study | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1097/INF.0b013e31819f7b3f | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Goldwater, P. [0000-0003-4822-8488] | - |
Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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