Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/51294
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Walker, S. | - |
dc.contributor.author | Carter, E. | - |
dc.contributor.author | Huff, B. | - |
dc.contributor.author | Morris, J. | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Chemical Reviews, 2009; 109(7):3080-3098 | - |
dc.identifier.issn | 0009-2665 | - |
dc.identifier.issn | 1520-6890 | - |
dc.identifier.uri | http://hdl.handle.net/2440/51294 | - |
dc.description.abstract | Variolin B, a novel marine alkaloid that was isolated from the rare and difficult-to-access, Antarctic sponge Kirkpatrickia varialosa by the group of Blunt and Munro, is a cyclin-dependent kinases (CDK). despite their modest size, the variolins presented a challenge in their structural elucidation because of the presence of several ring-nitrogen atoms and relatively few hydrogen atoms in the structure. Hernandez Franco and Palermo reported the isolation of five 3-(2-aminopyrimidine)indoles, which were named meridianins A-E from the tunicate Apidium meridianum which has been collected at a depth of 100 m near the South Georgia Islands. The aplicyanin family was isolated from the Antarctic tunicate Aplidium cyaneum and consists of six variants on a core 3-(tetrahydropyrimidyl) indole structure. Kuhn and co-workers used their modeling software SLIDE to identify variolin B as the top candidate for the inhibition of the AsnRS found in Brugia malayi. | - |
dc.description.statementofresponsibility | Scott R. Walker, Erin J. Carter, Belinda C. Huff, and Jonathan C. Morris | - |
dc.language.iso | en | - |
dc.publisher | Amer Chemical Soc | - |
dc.source.uri | http://dx.doi.org/10.1021/cr900032s | - |
dc.subject | Aza Compounds | - |
dc.subject | Indole Alkaloids | - |
dc.subject | Pyrimidines | - |
dc.subject | Cyclin-Dependent Kinases | - |
dc.subject | Antineoplastic Agents | - |
dc.subject | Bridged Bicyclo Compounds, Heterocyclic | - |
dc.title | Variolins and related alkaloids | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1021/cr900032s | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 5 Chemistry and Physics publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.