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https://hdl.handle.net/2440/51501
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Type: | Journal article |
Title: | Gastric emptying and the organization of antro-duodenal pressures in the critically ill |
Author: | Chapman, M. Fraser, R. Bryant, L. Yandell, R. Nguyen, Q. Tam, W. Zacharakis, B. Davidson, G. Butler, R. Horowitz, M. |
Citation: | Neurogastroenterology and Motility, 2008; 20(1):27-35 |
Publisher: | Blackwell Publishing Ltd |
Issue Date: | 2008 |
ISSN: | 1350-1925 1365-2982 |
Statement of Responsibility: | M. J. Chapman, R. J. Fraser, L. K. Bryant, R. Vozzo, N. Q. Nguyen, W. Tam, B. Zacharakis, G. Davidson,R. Butler & M. Horowitz |
Abstract: | The motor dysfunctions underlying delayed gastric emptying (GE) in critical illness are poorly defined. Our aim was to characterize the relationship between antro-duodenal (AD) motility and GE in critically ill patients. AD pressures were recorded in 15 mechanically ventilated patients and 10 healthy volunteers for 2 h (i) during fasting, (ii) following an intragastric nutrient bolus with concurrent assessment of GE using the (13)C-octanoate breath test and (iii) during duodenal nutrient infusion. Propagated waves were characterized by length and direction of migration. Critical illness was associated with: (i) slower GE (GEC: 3.47 +/- 0.1 vs 2.99 +/- 0.2; P = 0.046), (ii) fewer antegrade (duodenal: 44%vs 83%, AD: 16%vs 83%; P < 0.001) and more retrograde (duodenal: 46%vs 12%, AD: 38%vs 4%; P < 0.001) waves, (iii) shorter wave propagation (duodenal: 4.7 +/- 0.3 vs 6.0 +/- 0.4 cm; AD: 7.7 +/- 0.6 vs 10.9 +/- 0.9 cm; P = 0.004) and (iv) a close correlation between GE with the percentage of propagated phase 3 waves that were antegrade (r = 0.914, P = 0.03) and retrograde (r = -0.95, P = 0.014). In critical illness, the organization of AD pressure waves is abnormal and associated with slow GE. |
Keywords: | gastrointestinal motility intensive care manometry propagated pressure waves |
DOI: | 10.1111/j.1365-2982.2007.00984.x |
Published version: | http://dx.doi.org/10.1111/j.1365-2982.2007.00984.x |
Appears in Collections: | Aurora harvest Medicine publications |
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