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https://hdl.handle.net/2440/51528
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Type: | Journal article |
Title: | Event-related potentials to auditory stimuli in monozygotic twins discordant for combat: Association with PTSD |
Author: | Metzger, L. Clark, C. McFarlane, A. Veltmeyer, M. Lasko, M. Paige, S. Pitman, R. Orr, S. |
Citation: | Psychophysiology, 2009; 46(1):172-178 |
Publisher: | Cambridge Univ Press |
Issue Date: | 2009 |
ISSN: | 0048-5772 1469-8986 |
Statement of Responsibility: | Linda J. Metzger, C. Richard Clark, Alexander C. Mcfarlane, Melinda D. Veltmeyer, Natasha B. Lasko, Stephen R. Paige, Roger K. Pitman and Scott P. Orr |
Abstract: | Studies have demonstrated ERP abnormalities related to concentration difficulties in post-traumatic stress disorder (PTSD). We used an identical-twin, case-control design to investigate whether these abnormalities reflect pre-trauma vulnerability or the acquired consequence of PTSD. Vietnam combat veterans and their non-combat-exposed, identical twins completed a three-tone oddball task. Veterans with PTSD had delayed target N2 latencies compared to veterans without PTSD. In a small nonmedicated, nonsmoking subsample, veterans with PTSD also had significantly diminished target P3b amplitudes. A mixed-model, random-effects analysis on the nonmedicated, nonsmoking subsample that included the combat-unexposed co-twins showed a significant Diagnosis x Combat Exposure interaction for target P3b amplitude. Results replicate increased N2 latency and diminished P3b amplitude in PTSD and suggest that diminished P3b amplitude is an acquired condition in PTSD. |
Keywords: | Twin studies Post-traumatic stress disorder Event-related potentials P3b |
DOI: | 10.1111/j.1469-8986.2008.00720.x |
Published version: | http://dx.doi.org/10.1111/j.1469-8986.2008.00720.x |
Appears in Collections: | Aurora harvest 5 Psychiatry publications |
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