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https://hdl.handle.net/2440/51593
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Type: | Journal article |
Title: | A Preliminary Study on the Postoperative Survival of Patients Given Aspirin After Resection for Squamous Cell Carcinoma of the Esophagus or Adenocarcinoma of the Cardia |
Author: | Liu, J. Jamieson, G. Wu, T. Zhu, G. Drew, P. |
Citation: | Annals of Surgical Oncology, 2009; 16(5):1397-1402 |
Publisher: | Lippincott Williams & Wilkins |
Issue Date: | 2009 |
ISSN: | 1068-9265 1534-4681 |
Statement of Responsibility: | Jun-Feng Liu, Glyn G. Jamieson, Tie-Cheng Wu, Gui-Jun Zhu and Paul A. Drew |
Abstract: | Background We examined the effect of aspirin on survival following resection for squamous cell carcinoma (SCC) of the esophagus or adenocarcinoma of the gastric cardia. Methods Patients who underwent esophagectomy for these cancers between May 2000 and December 2002 were allocated to one of three groups and given daily either a low dose of aspirin, placebo, or no tablets. Results The 5-year survival for all patients on aspirin (445) was 51.2%, placebo (658) 41%, and no tablet (495) 42.3% (P = 0.04 for difference between treatments). The 5-year survival for all SCC patients on aspirin (267) was 49.8%, placebo (433) 42.2%, and no tablet (343) 41.2% (P = 0.26). There was a significant improvement in survival for patients with adenocarcinoma of the cardia on aspirin compared with the two control groups combined (P = 0.029). Survival for T2N0M0 SCC patients was significantly improved with aspirin (71) compared with placebo (167) or no tablet (134) (P = 0.0004). However, there was no significant difference between the survival curves for T2N0M0 adenocarcinoma patients on aspirin (21) and the two control groups combined (65) (P = 0.29). Conclusions The results of this preliminary study support further investigation of aspirin as adjuvant therapy to improve survival in subsets of postesophagectomy patients. |
Keywords: | Cardia Humans Adenocarcinoma Carcinoma, Squamous Cell Esophageal Neoplasms Stomach Neoplasms Cisplatin Aspirin Fluorouracil Etoposide Antineoplastic Combined Chemotherapy Protocols Combined Modality Therapy Chemotherapy, Adjuvant Radiotherapy, Adjuvant Esophagectomy Gastrectomy Survival Analysis Aged Middle Aged Female Male Cyclooxygenase 2 Inhibitors |
Description: | The original publication can be found at www.springerlink.com |
DOI: | 10.1245/s10434-009-0382-z |
Published version: | http://dx.doi.org/10.1245/s10434-009-0382-z |
Appears in Collections: | Aurora harvest Surgery publications |
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