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https://hdl.handle.net/2440/53330
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dc.contributor.author | Ogunniyi, A. | - |
dc.contributor.author | Paton, J. | - |
dc.contributor.author | Kirby, A. | - |
dc.contributor.author | McCullers, J. | - |
dc.contributor.author | Cook, J. | - |
dc.contributor.author | Hyodo, M. | - |
dc.contributor.author | Hayakawa, Y. | - |
dc.contributor.author | Karaolis, D. | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Vaccine, 2008; 26(36):4676-4685 | - |
dc.identifier.issn | 0264-410X | - |
dc.identifier.issn | 1873-2518 | - |
dc.identifier.uri | http://hdl.handle.net/2440/53330 | - |
dc.description | Copyright © 2008 Elsevier Ltd All rights reserved. | - |
dc.description.abstract | Cyclic diguanylate (c-di-GMP) is a unique bacterial intracellular signaling molecule capable of stimulating enhanced protective innate immunity against various bacterial infections. The effects of intranasal pretreatment with c-di-GMP, or intraperitoneal coadministration of c-di-GMP with the pneumolysin toxoid (PdB) or pneumococcal surface protein A (PspA) before pneumococcal challenge, were investigated in mice. We found that c-di-GMP had no significant direct short-term effect on the growth rate of Streptococcus pneumoniae either in vitro or in vivo. However, intranasal pretreatment of mice with c-di-GMP resulted in a significant decrease in bacterial load in lungs and blood after serotypes 2 and 3 challenge, and a significant decrease in lung titers after serotype 4 challenge. Potential cellular mediators of these enhanced protective responses were identified in lungs and draining lymph nodes. Intraperitoneal coadministration of c-di-GMP with PdB or PspA before challenge resulted in significantly higher antigen-specific antibody titers and increased survival of mice, compared to that obtained with alum adjuvant. These findings demonstrate that local or systemic c-di-GMP administration stimulates innate and adaptive immunity against invasive pneumococcal disease. We propose that c-di-GMP can be used as an effective broad spectrum immunomodulator and vaccine adjuvant to prevent infectious diseases. | - |
dc.description.statementofresponsibility | Abiodun D. Ogunniyi, James C. Paton, Alun C. Kirby, Jonathan A. McCullers, Jan Cook, Mamoru Hyodo, Yoshihiro Hayakawa and David K.R. Karaolis | - |
dc.description.uri | http://www.elsevier.com/wps/find/journaldescription.cws_home/30521/description#description | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Sci Ltd | - |
dc.source.uri | http://dx.doi.org/10.1016/j.vaccine.2008.06.099 | - |
dc.subject | Lung | - |
dc.subject | Lymph Nodes | - |
dc.subject | Blood | - |
dc.subject | Animals | - |
dc.subject | Mice, Inbred BALB C | - |
dc.subject | Mice | - |
dc.subject | Streptococcus pneumoniae | - |
dc.subject | Pneumococcal Infections | - |
dc.subject | Alum Compounds | - |
dc.subject | Bacterial Proteins | - |
dc.subject | Cyclic GMP | - |
dc.subject | Streptolysins | - |
dc.subject | Pneumococcal Vaccines | - |
dc.subject | Immunologic Factors | - |
dc.subject | Adjuvants, Immunologic | - |
dc.subject | Antibodies, Bacterial | - |
dc.subject | Colony Count, Microbial | - |
dc.subject | Administration, Intranasal | - |
dc.subject | Injections, Intraperitoneal | - |
dc.subject | Survival Analysis | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.title | C-di-GMP is an effective immunomodulator and vaccine adjuvant against pneumococcal infection | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.vaccine.2008.06.099 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/284214 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Ogunniyi, A. [0000-0001-9308-5629] | - |
dc.identifier.orcid | Paton, J. [0000-0001-9807-5278] | - |
Appears in Collections: | Aurora harvest 5 Molecular and Biomedical Science publications |
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