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https://hdl.handle.net/2440/53331
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Type: | Journal article |
Title: | Differential rates of apoptosis and recruitment limit eosinophil accumulation in the lungs of asthma-resistant CBA/Ca mice |
Author: | Tumes, D. Wong, A. Sewell, W. McColl, S. Connolly, A. Dent, L. |
Citation: | Molecular Immunology, 2008; 45(13):3609-3617 |
Publisher: | Pergamon-Elsevier Science Ltd |
Issue Date: | 2008 |
ISSN: | 0161-5890 1872-9142 |
Statement of Responsibility: | Damon J. Tumes, Alex C.H. Wong, William A. Sewell, Shaun R. McColl, Ashley Connolly and Lindsay A. Dent |
Abstract: | The accumulation of eosinophils is a common feature of allergic airway inflammation and correlates with disease severity. In an ovalbumin (OVA)-induced murine model of allergic lung disease, CBA/Ca mice develop much lower levels of lung eosinophilia, lung oedema, mucus hypersecretion and airways obstruction than BALB/c and C57BL/6 strains. In this study these strains have been examined to identify mechanisms that control the recruitment and survival of eosinophils in the allergic lung. Following immunization with OVA, CBA/Ca mice developed a robust systemic allergic response, with high levels of total and OVA-specific IgE and increases in peripheral blood eosinophils. Lung eotaxin-1 levels and expression of CD18 on eosinophils recovered by bronchoalveolar lavage (BAL) were least pronounced in CBA/Ca mice, whereas mRNA for L-selectin was highest in eosinophils from C57BL/6 mice. Apoptosis of BAL eosinophils ex vivo was most pronounced in the CBA/Ca strain. BALB/c mice expressed the highest levels of the eosinophil growth and survival factor interleukin (IL)-5 in the lungs and BAL eosinophils from these animals expressed more of the anti-apoptotic proteins Bcl-xL and Bcl-2 than cells from the other strains. A combination of lower levels of recruitment and rapid apoptosis may therefore limit the accumulation of eosinophils and pathology in the lungs of CBA/Ca mice. In addition, although the level of pathology that developed in C57BL/6 and BALB/c mice was similar, some of the underlying mechanisms are likely to differ. |
Keywords: | Lung Eosinophils Animals Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred CBA Mice, Transgenic Mice Asthma Bronchial Provocation Tests Leukocyte Count Immunization Apoptosis Chemotaxis, Leukocyte Immunity, Innate |
Description: | Copyright © 2008 Elsevier Ltd All rights reserved. |
DOI: | 10.1016/j.molimm.2008.05.002 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/253/description#description |
Published version: | http://dx.doi.org/10.1016/j.molimm.2008.05.002 |
Appears in Collections: | Aurora harvest 5 Molecular and Biomedical Science publications |
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