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https://hdl.handle.net/2440/53414
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dc.contributor.author | Madge, S. | - |
dc.contributor.author | Prabhakaran, V. | - |
dc.contributor.author | Shome, D. | - |
dc.contributor.author | Kim, U. | - |
dc.contributor.author | Honavar, S. | - |
dc.contributor.author | Selva-Nayagam, D. | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Orbit: the international journal on orbital disorders, oculoplastic and lacrimal surgery, 2008; 27(4):267-277 | - |
dc.identifier.issn | 0167-6830 | - |
dc.identifier.issn | 1744-5108 | - |
dc.identifier.uri | http://hdl.handle.net/2440/53414 | - |
dc.description.abstract | Purpose: To provide an up-to-date review of the clinical presentations, investigations, and management of orbital tuberculosis (OTB). Methods: Systematic review of the literature concerning OTB, limiting the results to English-language peer-reviewed journals. Results: Seventy-nine patients from 39 publications were identified as cases of OTB. The condition presents in one of five forms: classical periostitis; orbital soft tissue tuberculoma or cold abscess, with no bony involvement; OTB with bony involvement; spread from the paranasal sinuses; and tuberculous dacryoadenitis. The ocular adnexa, including the nasolacrimal system and overlying skin, may also be involved. Conclusions: Diagnosis can be difficult and may necessitate an orbital biopsy, in which acid-fast bacilli (AFB) and characteristic histopathology may be seen. Growth of Mycobacterium tuberculosis (mTB) from such a specimen remains the gold standard for diagnosis. Ancillary investigations include tuberculin skin tests and chest radiography, but more recently alternatives such as whole blood interferon-γ immunological tests and PCR-based tests of pathological specimens have proven useful. The management of OTB is complex, requiring a stringent public health strategy and high levels of patient adherence, combined with long courses of multiple anti-tuberculous medications. The interaction of the human immunodeficiency virus (HIV) with TB may further complicate management. | - |
dc.description.statementofresponsibility | Simon N. Madge, Venkatesh C. Prabhakaran, Debraj Shome, Usha Kim, Santosh Honavar and Dinesh Selva | - |
dc.language.iso | en | - |
dc.publisher | Taylor & Francis The Netherlands | - |
dc.source.uri | http://dx.doi.org/10.1080/01676830802225152 | - |
dc.subject | Orbit | - |
dc.subject | tuberculosis | - |
dc.subject | TB | - |
dc.subject | mycobacteria | - |
dc.title | Orbital tuberculosis: A review of the literature | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1080/01676830802225152 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Selva-Nayagam, D. [0000-0002-2169-5417] | - |
Appears in Collections: | Aurora harvest Opthalmology & Visual Sciences publications |
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