Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/53418
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Lactobacillus fermentum BR11 and fructo-oligosaccharide partially reduce jejunal inflammation in a model of intestinal mucositis in rats |
Author: | Smith, C. Geier, M. Yazbek, R. Torres, D. Butler, R. Howarth, G. |
Citation: | Nutrition and Cancer: an international journal, 2008; 60(6):757-767 |
Publisher: | Lawrence Erlbaum Assoc Inc |
Issue Date: | 2008 |
ISSN: | 0163-5581 1532-7914 |
Statement of Responsibility: | Cassie L. Smith, Mark S. Geier, Roger Yazbeck, Diana M. Torres, Ross N. Butler and Gordon S. Howarth |
Abstract: | Although probiotics are beginning to enter mainstream medicine for disorders of the colon, their effects on the small bowel remain largely unexplored. We investigated the recently identified probiotic, Lactobacillus fermentum (L. fermentum) BR11 (BR11) and the prebiotic, fructo-oligosaccharide (FOS), both individually and in synbiotic combination, for their potential to alleviate intestinal mucositis. From Days 0-9, rats consumed skim milk (SM; saline + SM), low dose (LD-BR11; 1 106cfu/ml), high dose (HD-BR11; 1 109cfu/ml), LD-FOS (3%), HD-FOS (6%), or synbiotic (HD-BR11/FOS). On Day 7, rats were injected with 5-fluorouracil (5-FU; 150 mg/kg). All rats were sacrificed on Day 10. Intestinal tissues were collected for quantitative histology, sucrase, and myeloperoxidase (MPO) determinations. 5-FU decreased sucrase activity, villus height, crypt depth, and crypt cell proliferation compared to controls. Compared to 5-FU + SM, histological damage severity scores were increased for all treatments, although all were effective at reducing jejunal inflammation, indicated by reduced MPO activity (P < 0.05). The combination of BR11 and FOS did not provide additional protection. Moreover, HD-FOS and the synbiotic actually increased clinical mucositis severity (P < 0.05). We conclude that L. fermentum BR11 has the potential to reduce inflammation of the upper small intestine. However, its combination with FOS does not appear to confer any further therapeutic benefit for the alleviation of mucositis |
Keywords: | Jejunum Animals Rats Body Weight Fluorouracil Sucrase Peroxidase Oligosaccharides Organ Size Probiotics Female Mucositis Limosilactobacillus fermentum |
DOI: | 10.1080/01635580802192841 |
Published version: | http://dx.doi.org/10.1080/01635580802192841 |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.