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https://hdl.handle.net/2440/53848
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dc.contributor.author | Luke, C. | - |
dc.contributor.author | Koczwara, B. | - |
dc.contributor.author | Karapetis, C. | - |
dc.contributor.author | Pittman, K. | - |
dc.contributor.author | Price, T. | - |
dc.contributor.author | Kotasek, D. | - |
dc.contributor.author | Beckmann, K. | - |
dc.contributor.author | Brown, M. | - |
dc.contributor.author | Roder, D. | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Australian and New Zealand Journal of Public Health, 2008; 32(4):383-389 | - |
dc.identifier.issn | 1326-0200 | - |
dc.identifier.issn | 1753-6405 | - |
dc.identifier.uri | http://hdl.handle.net/2440/53848 | - |
dc.description.abstract | Objectives: To investigate incidence, mortality and case survival trends for cancer of unknown primary site (CUP) and consider clinical implications. Method: South Australian Cancer Registry data were used to calculate age-standardised incidence and mortality rates from 1977 to 2004. Disease-specific survivals, socio-demographic, histological and secular predictors of CUP, compared with cancers of known primary site, and of CUP histological types, using multivariable logistic regression were investigated. Results: Incidence and mortality rates increased approximately 60% between 1977-80 and 1981-84. Rates peaked in 1993-96. Male to female incidence and mortality rate ratios approximated 1.3:1. Incidence and mortality rates increased with age. The odds of unspecified histological type, compared with the more common adenocarcinomas, were higher for males than females, non-metropolitan residents, low socio-economic areas, and for 1977-88 than subsequent diagnostic periods. CUP represented a higher proportion of cancers in Indigenous patients. Case survival was 7% at 10 years from diagnosis. Factors predictive of lower case survival included older age, male sex, Indigenous status, lower socio-economic status, and unspecified histology type. Conclusion: Results point to poor CUP outcomes, but with a modest improvement in survival. The study identifies socio-demographic groups at elevated risk of CUP and of worse treatment outcomes where increased research and clinical attention are required. | - |
dc.description.statementofresponsibility | Colin Luke, Bogda Koczwara, Christos Karapetis, Ken Pittman, Tim Price, Dusan Kotasek, Kerry Beckmann, Michael P. Brown and David Roder | - |
dc.language.iso | en | - |
dc.publisher | Public Health Assoc Australia Inc | - |
dc.rights | © 2008 The Berkeley Electronic Press | - |
dc.source.uri | http://dx.doi.org/10.1111/j.1753-6405.2008.00260.x | - |
dc.subject | Humans | - |
dc.subject | Neoplasms, Unknown Primary | - |
dc.subject | Epidemiologic Methods | - |
dc.subject | Registries | - |
dc.subject | Incidence | - |
dc.subject | Logistic Models | - |
dc.subject | Risk Factors | - |
dc.subject | Epidemiologic Studies | - |
dc.subject | Pilot Projects | - |
dc.subject | Public Health | - |
dc.subject | Public Health Practice | - |
dc.subject | Socioeconomic Factors | - |
dc.subject | Adult | - |
dc.subject | Aged | - |
dc.subject | Aged, 80 and over | - |
dc.subject | Middle Aged | - |
dc.subject | South Australia | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Practice Patterns, Physicians' | - |
dc.title | Exploring the epidemiological characteristics of cancers of unknown primary site in an Australian population: implications for research and clinical care | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/j.1753-6405.2008.00260.x | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Price, T. [0000-0002-3922-2693] | - |
dc.identifier.orcid | Brown, M. [0000-0002-5796-1932] [0000-0002-6678-1407] | - |
dc.identifier.orcid | Roder, D. [0000-0001-6442-4409] | - |
Appears in Collections: | Aurora harvest Public Health publications |
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