Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/53872
Type: | Journal article |
Title: | CD 271 (p75 neurotrophin receptor) |
Author: | Rogers, M. Beare, A. Zola, H. Rush, R. |
Citation: | Journal of Biological Regulators and Homeostatic Agents, 2008; 22(1):1-6 |
Publisher: | Wichtig Editore |
Issue Date: | 2008 |
ISSN: | 0393-974X 1724-6083 |
Statement of Responsibility: | M-L. Rogers, A. Beare, H. Zola and R.A. Rush |
Abstract: | CD271, (or p75NTR) is the sixteenth member of the Tumor Necrosis Factor receptor (TNFR) super family of transmembrane proteins. Members of the TNFR family including CD271, share homology in their extracellular domain, and have a cytoplasmic death domain, although CD271 has unique intracellular structure and downstream signalling partners. CD271 is also differentiated from other members of the TNFR receptor family in that it binds pro and mature neurotrophins and affects the growth, differentiation and death of the nervous system. The ligands for CD271 are neurotrophins, which are Nerve Growth Factor (NGF), Brain-Derived Growth factor (BDNF), Neurotrophin 3 (NT3) and Neurotrophin 4/5 (NT4/5). Recent studies have provided evidence that CD271 also serves as a receptor for the pro-forms of these neurotrophins. |
Keywords: | TFN receptor NGF BDNF neuron P75 monoclonal antibody |
Rights: | Copyright © by BIOLIFE, s.a.s. |
Description (link): | http://www.biolifesas.org/contentsJBRHA.htm |
Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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