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https://hdl.handle.net/2440/55087
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Type: | Journal article |
Title: | Carbapenem Resistance among Pseudomonas aeruginosa Strains from India: Evidence for Nationwide Endemicity of Multiple Metallo-beta-Lactamase Clones (VIM-2,-5,-6, and-11 and the Newly Characterized VIM-18) |
Author: | Castanheira, M. Bell, J. Turnidge, J. Mathai, D. Jones, R. |
Citation: | Antimicrobial Agents and Chemotherapy, 2009; 53(3):1225-1227 |
Publisher: | Amer Soc Microbiology |
Issue Date: | 2009 |
ISSN: | 0066-4804 1098-6596 |
Statement of Responsibility: | Mariana Castanheira, Jan M. Bell, John D. Turnidge, Dillip Mathai and Ronald N. Jones |
Abstract: | Among 57 metallo-beta-lactamase (MbetaL)-producing Pseudomonas spp. detected in India during 2006, five bla(VIM) genes were found, including a newly characterized bla(VIM) gene. Pseudomonas aeruginosa strains were clustered in 33 ribotypes with clones found in multiple hospitals. Several types of bla(VIM-2)-carrying integrons were detected. The newly characterized variant VIM-18 showed a 4-amino-acid deletion compared to other VIM variants. In this study, we show that VIM-producing Pseudomonas spp. were highly prevalent in India with a great diversity of bla(VIM) types and MbetaL-carrying integrons. |
Keywords: | Humans Pseudomonas aeruginosa Carbapenems beta-Lactamases Bacterial Proteins Anti-Bacterial Agents Ribotyping Microbial Sensitivity Tests Prevalence Drug Resistance, Bacterial Base Sequence Molecular Sequence Data India |
DOI: | 10.1128/AAC.01011-08 |
Published version: | http://dx.doi.org/10.1128/aac.01011-08 |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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