Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/55270
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, X. | - |
dc.contributor.author | Zhou, F. | - |
dc.contributor.author | Zhong, J. | - |
dc.contributor.author | Linyan Wu, L. | - |
dc.contributor.author | Zhou, X. | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Journal of Neurochemistry, 2006; 96(3):833-842 | - |
dc.identifier.issn | 0022-3042 | - |
dc.identifier.issn | 1471-4159 | - |
dc.identifier.uri | http://hdl.handle.net/2440/55270 | - |
dc.description.abstract | Remyelination is an important aspect of nerve regeneration after nerve injury but the underlying mechanisms are not fully understood. The neurotrophin receptor, p75NTR, in activated Schwann cells in the Wallerian degenerated nerve is up-regulated and may play a role in the remyelination of regenerating peripheral nerves. In the present study, the role of p75NTR in remyelination of the sciatic nerve was investigated in p75NTR mutant mice. Histological results showed that the number of myelinated axons and thickness of myelin sheath in the injured sciatic nerves were reduced in mutant mice compared with wild-type mice. The myelin sheath of axons in the intact sciatic nerve of adult mutant mice is also thinner than that of wild-type mice. Real-time RT–PCR showed that mRNA levels for myelin basic protein and P0 in the injured sciatic nerves were significantly reduced in p75NTR mutant animals. Western blots also showed a significant reduction of P0 protein in the injured sciatic nerves of mutant animals. These results suggest that p75NTR is important for the myelinogenesis during the regeneration of peripheral nerves after injury. | - |
dc.description.statementofresponsibility | Xing-Yun Song, Fiona H-H. Zhou, Jin-Hua Zhong, Linda L. Y. Wu and Xin-Fu Zhou | - |
dc.language.iso | en | - |
dc.publisher | Blackwell Publishing Ltd | - |
dc.source.uri | http://dx.doi.org/10.1111/j.1471-4159.2005.03564.x | - |
dc.subject | injury | - |
dc.subject | myelin | - |
dc.subject | neurotrophic | - |
dc.subject | regeneration | - |
dc.subject | Schwann cell | - |
dc.subject | sciatic | - |
dc.title | Knockout of p75NTR impairs re-myelination of injured sciatic nerve in mice | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/j.1471-4159.2005.03564.x | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Zhou, F. [0000-0003-3113-1671] | - |
dc.identifier.orcid | Zhou, X. [0000-0002-8687-0175] | - |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.