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https://hdl.handle.net/2440/55388
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dc.contributor.author | Stark, M. | - |
dc.contributor.author | Clifton, V. | - |
dc.contributor.author | Wright, I. | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Pediatric Research, 2008; 63(4):415-419 | - |
dc.identifier.issn | 0031-3998 | - |
dc.identifier.issn | 1530-0447 | - |
dc.identifier.uri | http://hdl.handle.net/2440/55388 | - |
dc.description | Copyright © 2008 International Pediatric Research Foundation, Inc. | - |
dc.description.abstract | Microvascular blood flow is related to physiologic instability in newborn preterm infants. We investigated sex-specific differences in basal microvascular blood flow and the ability of the microvasculature to respond to vasoactive stimuli following preterm birth. Ninety-six infants in two gestational age groups (24-28 and 29-36 wk) were studied on days 1-5 of life. Laser Doppler flowmetry was used to measure baseline microvascular blood flow and vasodilatation in response to acetylcholine and local warming. A significant interaction of gestational age and sex was observed for baseline flow at 24 h of age. In the 24-28 wk group, male infants had higher baseline flow than females. Male, but not female, infants born at 24-28 wk exhibited a significant relationship between baseline flow and vasodilatory response to acetylcholine at 24 h of age. By 120 h of age, both sexes exhibited similar responses. Infants born at 24-28 wk exhibited greater vasodilatation in response to local warming than those born at 29-36 wk at 24, 72, and 120 h of age. Sex-specific differences in microvascular blood flow and vasodilatory capacity in the immediate newborn period may affect the transitional circulation, contributing to excess of morbidity and mortality in preterm males. | - |
dc.description.statementofresponsibility | Michal J. Stark, Vicki L. Clifton, and Ian M. R. Wright | - |
dc.language.iso | en | - |
dc.publisher | Int Pediatric Research Foundation Inc | - |
dc.source.uri | http://dx.doi.org/10.1203/01.pdr.0000304937.38669.63 | - |
dc.subject | Microcirculation | - |
dc.subject | Humans | - |
dc.subject | Acetylcholine | - |
dc.subject | Vasodilator Agents | - |
dc.subject | Laser-Doppler Flowmetry | - |
dc.subject | Aging | - |
dc.subject | Sex Characteristics | - |
dc.subject | Regional Blood Flow | - |
dc.subject | Vasodilation | - |
dc.subject | Infant, Newborn | - |
dc.subject | Infant, Premature | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.title | Sex-Specific Differences in Peripheral Microvascular Blood Flow in Preterm Infants | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1203/01.pdr.0000304937.38669.63 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Stark, M. [0000-0003-1835-8679] | - |
dc.identifier.orcid | Clifton, V. [0000-0002-4892-6748] | - |
Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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