Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/5644
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | A comparison of the disease-modifying and cytokine-regulating activities of tenidap, piroxicam and cyclosporin-A using the adjuvant-induced model of arthritis in rats |
Author: | Haynes, D. Hutchens, M. Whitehouse, M. Vernon-Roberts, B. |
Citation: | Inflammopharmacology: experimental and clinical studies, 1998; 6(3):193-202 |
Publisher: | Springer Science and Business Media LLC |
Issue Date: | 1998 |
ISSN: | 0925-4692 1568-5608 |
Statement of Responsibility: | D. R. Haynes, M. J. Hutchens, M. W. Whitehouse, B. Vernon-Roberts |
Abstract: | This study compared the antiarthritic activity of tenidap, piroxicam and cyclosporin-A (CsA) using the model of adjuvant-induced arthritis in rats. The aim of the study was to correlate any disease-modifying effects of tenidap with its in-vivo regulation of cytokines. Both tenidap and piroxicam reduced arthritic disease when administered orally from the time the first signs of arthritis are expressed. Disease suppression correlated with a significant reduction in interleukin-6 production and a slight reduction in interleukin-1 and tumour necrosis factor production. When coadministered with the adjuvant, tenidap and CsA prevented disease in 50% and 100% of animals, respectively, whereas piroxicam had no effect. This disease prevention induced by tenidap and CsA coincided with reduced interferon-γ and interleukin-2 production by lymph node cells one day following initiation of adjuvant disease. This inhibition of T-cell cytokines might be consistent with tenidap acting as a disease-modifying drug. |
Rights: | © Springer, Part of Springer Science+Business Media |
DOI: | 10.1007/s10787-998-0019-z |
Published version: | http://dx.doi.org/10.1007/s10787-998-0019-z |
Appears in Collections: | Aurora harvest 5 Pathology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.