Adelaide Research & Scholarship
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https://hdl.handle.net/2440/56457
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| Type: | Journal article |
| Title: | Efficient Large-Scale Synthesis of CAT811, a Potent Calpain Inhibitor of Interest in the Treatment of Cataracts |
| Author: | Jones, M. Coxon, J. McNabb, S. Mehrtens, J. Alexander, N. Jones, S. Chen, H. Buisan, C. Abell, A. |
| Citation: | Australian Journal of Chemistry: an international journal for chemical science, 2009; 62(7):671-675 |
| Publisher: | C S I R O Publishing |
| Issue Date: | 2009 |
| ISSN: | 0004-9425 1445-0038 |
| Statement of Responsibility: | Matthew A. Jones, James M. Coxon, Stephen B. McNabb, Janna M. Mehrtens, Nathan A. Alexander, Seth Jones, Hongyuan Chen, Clémence Buisan and Andrew D. Abell |
| Abstract: | A high-yielding, short, and scalable synthesis of a potent calpain 2 inhibitor (CAT811) is reported. The key step in the sequence involves an intramolecular macrocyclization of a 6-iodonorleucine residue to the side chain of tyrosine. |
| Description: | © CSIRO 2009 |
| DOI: | 10.1071/CH09101 |
| Published version: | http://dx.doi.org/10.1071/ch09101 |
| Appears in Collections: | Aurora harvest Chemistry and Physics publications |
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