Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/56990
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Brown, J. | - |
dc.contributor.author | Jones, E. | - |
dc.contributor.author | Forbes, B. | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Trends in Biochemical Sciences, 2009; 34(12):612-619 | - |
dc.identifier.issn | 0968-0004 | - |
dc.identifier.issn | 1362-4326 | - |
dc.identifier.uri | http://hdl.handle.net/2440/56990 | - |
dc.description.abstract | Insulin-like growth factor-II (IGF-II) is a key regulator of cell growth, survival, migration and differentiation. Its pivotal role in these processes requires tight regulation of both expression and activity. The type 1 IGF receptor tyrosine kinase (IGF-1R) mediates IGF-II actions, and a family of six high affinity IGF binding proteins (IGFBPs) regulates IGF-II circulating half-life and its availability to bind IGF-1R. In addition, the type 2 IGF receptor (IGF2R; also called the cation-independent mannose-6-phosphate receptor) modulates the circulating and tissue levels of IGF-II by targeting it to lysosomes for degradation. The recently elucidated crystal structure of IGFII– IGF2R complex provides new insight into IGF-II regulation, and reveals a common binding surface on IGF-II for the regulatory proteins, IGF2R and the IGFBPs. | - |
dc.description.statementofresponsibility | James Brown, E. Yvonne Jones and Briony E. Forbes | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Science London | - |
dc.source.uri | http://dx.doi.org/10.1016/j.tibs.2009.07.003 | - |
dc.subject | Animals | - |
dc.subject | Humans | - |
dc.subject | Insulin-Like Growth Factor II | - |
dc.subject | Receptor, IGF Type 2 | - |
dc.subject | Binding Sites | - |
dc.subject | Protein Structure, Secondary | - |
dc.subject | Protein Structure, Tertiary | - |
dc.subject | Protein Binding | - |
dc.title | Keeping IGF-II under control: Lessons from the IGF-II-IGF2R crystal structure | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.tibs.2009.07.003 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.