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https://hdl.handle.net/2440/5859
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dc.contributor.author | Mullighan, C. | - |
dc.contributor.author | Heatley, S. | - |
dc.contributor.author | Doherty, K. | - |
dc.contributor.author | Szabo, F. | - |
dc.contributor.author | Grigg, A. | - |
dc.contributor.author | Hughes, T. | - |
dc.contributor.author | Schwarer, A. | - |
dc.contributor.author | Szer, J. | - |
dc.contributor.author | Tait, B. | - |
dc.contributor.author | To, L. | - |
dc.contributor.author | Bardy, P. | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Transplantation, 2004; 27(4):587-596 | - |
dc.identifier.issn | 0041-1337 | - |
dc.identifier.issn | 1534-6080 | - |
dc.identifier.uri | http://hdl.handle.net/2440/5859 | - |
dc.description.abstract | <h4>Background</h4>Existing data indicate that non-human leukocyte antigen (HLA) immunogenetic polymorphisms influence the risk of complications after allogeneic hemopoietic stem-cell transplantation. However, prior studies have been limited by small sample size and limited genotyping.<h4>Methods</h4>We examined 22 polymorphisms in 11 immunoregulatory genes including cytokines, mediators of apoptosis, and host-defense molecules by polymerase chain reaction using sequence-specific primers in 160 related myeloablative transplants. Associations were confirmed in two independent cohorts.<h4>Results</h4>An intronic polymorphism in the tumor necrosis factor gene (TNF 488A) was associated with the risk of acute graft-versus-host disease (GVHD) (odds ratio [OR] 16.9), grades II to IV acute GVHD (OR 3.3), chronic GVHD (OR 12.5), and early death posttransplant (OR 3.4). Recipient Fas -670G and donor interleukin (IL)-6 -174G were independent risk factors for acute GVHD. Recipient IL-10 ATA and Fas -670 genotype were independent risk factors for chronic GVHD. Recipient IL-1beta +3953T was associated with hepatic acute GVHD, and Fas -670G was associated with major infection.<h4>Conclusions</h4>These results highlight the potential importance of cytokine and apoptosis gene polymorphisms in stem-cell transplantation, and indicate that non-HLA genotyping may be useful to identify individuals at the highest risk of complications and new targets for therapeutic intervention. | - |
dc.description.statementofresponsibility | Mullighan, Charles; Heatley, Sue; Doherty, Kathleen; Szabo, Ferenc; Grigg, Andrew; Hughes, Timothy; Schwarer, Anthony, Szer, Jeff; Tait, Brian; To, Bik; Bardy, Peter | - |
dc.language.iso | en | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.source.uri | http://dx.doi.org/10.1097/01.tp.0000111769.45088.a2 | - |
dc.subject | Blood Cells | - |
dc.subject | Humans | - |
dc.subject | Graft vs Host Disease | - |
dc.subject | Chronic Disease | - |
dc.subject | Genetic Predisposition to Disease | - |
dc.subject | Methotrexate | - |
dc.subject | Cyclosporine | - |
dc.subject | Tumor Necrosis Factor-alpha | - |
dc.subject | Immunosuppressive Agents | - |
dc.subject | Interleukins | - |
dc.subject | Drug Therapy, Combination | - |
dc.subject | Bone Marrow Transplantation | - |
dc.subject | Hematopoietic Stem Cell Transplantation | - |
dc.subject | Transplantation, Homologous | - |
dc.subject | Cohort Studies | - |
dc.subject | Polymorphism, Genetic | - |
dc.subject | Adult | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | fas Receptor | - |
dc.title | Non-HLA immunogenetic polymorphisms and the risk of complications after allogeneic hemopoietic stem-cell transplantation | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1097/01.TP.0000111769.45088.A2 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Mullighan, C. [0000-0002-1871-1850] | - |
dc.identifier.orcid | Heatley, S. [0000-0001-7497-6477] | - |
dc.identifier.orcid | Hughes, T. [0000-0002-0910-3730] [0000-0002-7990-4509] | - |
Appears in Collections: | Aurora harvest 5 Pathology publications |
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