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https://hdl.handle.net/2440/58657
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dc.contributor.author | Roughead, E. | - |
dc.contributor.author | Ramsay, E. | - |
dc.contributor.author | Pratt, N. | - |
dc.contributor.author | Ryan, P. | - |
dc.contributor.author | Gilbert, A. | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Medical Journal of Australia, 2009; 190(3):114-116 | - |
dc.identifier.issn | 0025-729X | - |
dc.identifier.issn | 1326-5377 | - |
dc.identifier.uri | http://hdl.handle.net/2440/58657 | - |
dc.description.abstract | Objective: To determine whether proton-pump inhibitor (PPI) use is associated with hospitalisations for pneumonia and with antibiotic use. Design and setting: Historical cohort study in the Australian veteran population, conducted from 1 January 2002 to 30 December 2006, comparing veterans exposed to PPIs with those not exposed. Participants: All 185 533 veterans who were Gold Card holders (ie, eligible for all health services subsidised by the Department of Veterans’ Affairs) and aged 65 years and over at 1 January 2002 and had been prescribed at least one medicine in the previous 6 months. Main outcome measures: The primary endpoint was hospitalisation for pneumonia. Secondary endpoints included hospitalisation for bacterial pneumonia and dispensings of antibiotics commonly used to treat respiratory tract infections. Results: After adjustment for potential confounders, we found an increased risk of hospitalisation for pneumonia among those exposed to PPIs compared with the unexposed group (rate ratio [RR], 1.16; 95% CI, 1.11–1.22). The risk was not increased for bacterial pneumonia (RR, 1.13; 95% CI, 0.98–1.31), which made up 8% of pneumonia cases. An increased risk of antibiotic dispensings was observed among those exposed to PPIs (RR, 1.23; 95% CI, 1.21–1.24). Conclusions: PPI dispensings were found to be associated with a small but significant increased risk of hospitalisation for pneumonia. While the increased risk is small, the prevalent use of PPIs means that many people could be affected. | - |
dc.description.statementofresponsibility | Elizabeth E Roughead, Emmae N Ramsay, Nicole L Pratt, Philip Ryan and Andrew L Gilbert | - |
dc.language.iso | en | - |
dc.publisher | Australasian Med Publ Co Ltd | - |
dc.rights | © The Medical Journal of Australia 2009 | - |
dc.source.uri | http://www.mja.com.au/public/issues/190_03_020209/rou10521_fm.html | - |
dc.subject | Humans | - |
dc.subject | Pneumonia, Bacterial | - |
dc.subject | Anti-Bacterial Agents | - |
dc.subject | Hospitalization | - |
dc.subject | Confidence Intervals | - |
dc.subject | Risk Assessment | - |
dc.subject | Risk Factors | - |
dc.subject | Cohort Studies | - |
dc.subject | Aged | - |
dc.subject | Veterans Disability Claims | - |
dc.subject | Drug Utilization | - |
dc.subject | Australia | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Proton Pump Inhibitors | - |
dc.title | Proton-pump inhibitors and the risk of antibiotic use and hospitalisation for pneumonia | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.5694/j.1326-5377.2009.tb02307.x | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Pratt, N. [0000-0001-8730-8910] | - |
Appears in Collections: | Aurora harvest Public Health publications |
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