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https://hdl.handle.net/2440/5974
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Type: | Journal article |
Title: | GABAB receptors: targets for drug development |
Author: | Kerr, D. Ong, J. |
Citation: | Drug Discovery Today, 1996; 1(9):371-380 |
Publisher: | Elsevier BV |
Issue Date: | 1996 |
ISSN: | 1359-6446 |
Abstract: | GABA is a major inhibitory neurotransmitter in the CNS where it regulates neuronal excitability. These actions of GABA are mediated through GABA receptor sub-types, one of which is the GABAB receptor (GBR). The development of specific agonists and antagonists for GBRs has led to a better understanding of their functional roles, which mainly focus on the long-term modulation of neural activity. In this review, the authors emphasize the current knowledge of the structure-action profile of compounds active at GBRs, characterizing their physiology and pharmacology and highlighting their potential as targets for drug development. |
DOI: | 10.1016/1359-6446(96)10034-9 |
Published version: | http://dx.doi.org/10.1016/1359-6446(96)10034-9 |
Appears in Collections: | Anaesthesia and Intensive Care publications Aurora harvest 5 |
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