Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/5986
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ong, J. | - |
dc.contributor.author | Kerr, D. | - |
dc.date.issued | 1995 | - |
dc.identifier.citation | European Journal of Pharmacology, 1995; 287(2):197-200 | - |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.issn | 1879-0712 | - |
dc.identifier.uri | http://hdl.handle.net/2440/5986 | - |
dc.description.abstract | Interactions of N-ethylmaleimide and aluminium fluoride (AlF - 4) with GABAB receptors have been examined using spontaneously discharging rat neocortical slices. The suppression of discharges by the GABAB receptor agonist baclofen (5-10 mu M) was irreversibly prevented by N-ethylmaleimide (10-50 mu M) and its analog N-phenylmaleimide (10-50 mu M), whilst superfusion of slices with NaF (10 mM) and AlCl3 (100 mu M) to form a fluoroaluminate (AlF - 4) complex markedly potentiated the action of baclofen. The lipoxygenase inhibitors, nordihydroguaiaretic acid (10-50 mu M) and eicosatetraynoic acid (10-50 mu M) or the phospholipase A2 inhibitor bromophenacylbromide (50-100 mu M) did not affect the response to baclofen. The depressant action of baclofen is evidently mediated through G-proteins, but is not dependent on arachidonic acid metabolites. | - |
dc.language.iso | en | - |
dc.publisher | North Holland | - |
dc.source.uri | http://dx.doi.org/10.1016/0014-2999(95)00659-1 | - |
dc.subject | Cerebral Cortex | - |
dc.subject | Animals | - |
dc.subject | Rats | - |
dc.subject | Rats, Sprague-Dawley | - |
dc.subject | Aluminum Compounds | - |
dc.subject | Baclofen | - |
dc.subject | Ethylmaleimide | - |
dc.subject | Receptors, GABA-B | - |
dc.subject | Membrane Potentials | - |
dc.subject | Drug Interactions | - |
dc.subject | Male | - |
dc.title | Interactions of N-ethylmaleimide and aluminium fluoride with GABAB receptor function in rat neocortical slices | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/0014-2999(95)00659-1 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Ong, J. [0000-0002-0958-460X] | - |
Appears in Collections: | Anaesthesia and Intensive Care publications Aurora harvest 5 |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.