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Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/5993
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dc.contributor.authorOng, J.-
dc.contributor.authorKerr, D.-
dc.contributor.authorVaccher, C.-
dc.contributor.authorBerthelot, P.-
dc.date.issued1997-
dc.identifier.citationEuropean Journal of Pharmacology, 1997; 329(2-3):133-136-
dc.identifier.issn0014-2999-
dc.identifier.issn1879-0712-
dc.identifier.urihttp://hdl.handle.net/2440/5993-
dc.descriptionShort communication-
dc.description.abstractIn rat neocortical slices maintained in Mg2+-free Krebs medium, baclofen and its thienyl analogs, 4-amino-3-(5-chlorothien-2-yl)-butanoic acid (5h), 4-amino-3-(5-methylthien-2-yl)-butanoic acid (5d), 4-amino-3-(5-bromothien-2-yl)-butanoic acid (5f) and 4-amino-3-(thien-3-yl)-butanoic acid (5j) dose-dependently suppressed the spontaneous discharges, antagonised by the GABA(B) receptor antagonist 2-hydroxysaclofen (200 microM). Their relative potencies were baclofen > 5h > 5d > 5f > 5j. These heterocyclic analogs may prove useful as GABA(B) receptor agonists in functional studies.-
dc.description.statementofresponsibilityJennifer Ong, David I.B. Kerr, Claude Vaccher, Pascal Berthelot-
dc.language.isoen-
dc.publisherElsevier BV-
dc.rights© 1997 Elsevier Science B.V.-
dc.source.urihttp://dx.doi.org/10.1016/s0014-2999(97)00185-4-
dc.subjectBaclofen: GABAB receptor agonist-
dc.subjectThienyl baclofen analog-
dc.subject2-Hydroxysaclofen-
dc.subjectNeocortical slice, rat-
dc.titleActions of thienyl analogs of baclofen at GABAB receptors in rat neocortical slices-
dc.title.alternativeActions of thienyl analogs of baclofen at GABA(B) receptors in rat neocortical slices-
dc.typeJournal article-
dc.identifier.doi10.1016/S0014-2999(97)00185-4-
pubs.publication-statusPublished-
dc.identifier.orcidOng, J. [0000-0002-0958-460X]-
Appears in Collections:Anaesthesia and Intensive Care publications
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