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PreviewIssue DateTitleAuthor(s)
2019OBI-3424, a novel AKR1c3-activated prodrug, exhibits potent efficacy against preclinical models of T-ALLEvans, K.; Duan, J.X.; Pritchard, T.; Jones, C.D.; McDermott, L.; Gu, Z.; Toscan, C.E.; El-Zein, N.; Mayoh, C.; Erickson, S.W.; Guo, Y.; Meng, F.; Jung, D.; Rathi, K.S.; Roberts, K.G.; Mullighan, C.G.; Shia, C.S.; Pearce, T.; Teicher, B.A.; Smith, M.A.; et al.
2020The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1Carmichael, C.L.; Wang, J.; Nguyen, T.; Kolawole, O.; Benyoucef, A.; De Mazière, C.; Milne, A.R.; Samuel, S.; Gillinder, K.; Hediyeh-Zadeh, S.; Vo, A.N.Q.; Huang, Y.; Knezevic, K.; McInnes, W.R.L.; Shields, B.J.; Mitchell, H.; Ritchie, M.E.; Lammens, T.; Lintermans, B.; Van Vlierberghe, P.; et al.
2019Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancerWatt, M.J.; Clark, A.K.; Selth, L.A.; Haynes, V.R.; Lister, N.; Rebello, R.; Porter, L.H.; Niranjan, B.; Whitby, S.T.; Lo, J.; Huang, C.; Schittenhelm, R.B.; Anderson, K.E.; Furic, L.; Wijayaratne, P.R.; Matzaris, M.; Montgomery, M.K.; Papargiris, M.; Norden, S.; Febbraio, M.; et al.
2021Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanomaJacquelot, N.; Seillet, C.; Wang, M.; Pizzolla, A.; Liao, Y.; Hediyeh-Zadeh, S.; Grisaru-Tal, S.; Louis, C.; Huang, Q.; Schreuder, J.; Souza-Fonseca-Guimaraes, F.; de Graaf, C.A.; Thia, K.; Macdonald, S.; Camilleri, M.; Luong, K.; Zhang, S.; Chopin, M.; Molden-Hauer, T.; Nutt, S.L.; et al.
2021Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: guidance using optical window intravital FRET imagingFloerchinger, A.; Murphy, K.J.; Latham, S.L.; Warren, S.C.; McCulloch, A.T.; Lee, Y.-K.; Stoehr, J.; Mélénec, P.; Guaman, C.S.; Metcalf, X.L.; Lee, V.; Zaratzian, A.; Da Silva, A.; Tayao, M.; Rolo, S.; Phimmachanh, M.; Sultani, G.; McDonald, L.; Mason, S.M.; Ferrari, N.; et al.
2019DNA hypermethylation encroachment at CpG island borders in cancer is predisposed by H3K4 monomethylation patternsSkvortsova, K.; Masle-Farquhar, E.; Luu, P.L.; Song, J.Z.; Qu, W.; Zotenko, E.; Gould, C.M.; Du, Q.; Peters, T.J.; Colino-Sanguino, Y.; Pidsley, R.; Nair, S.S.; Khoury, A.; Smith, G.C.; Miosge, L.A.; Reed, J.H.; Kench, J.G.; Rubin, M.A.; Horvath, L.; Bogdanovic, O.; et al.
2018Tight junction protein claudin-2 promotes self-renewal of human colorectal cancer stem-like cellsPaquet-Fifield, S.; Koh, S.L.; Cheng, L.; Beyit, L.M.; Shembrey, C.; Mølck, C.; Behrenbruch, C.; Papin, M.; Gironella, M.; Guelfi, S.; Nasr, R.; Grillet, F.; Prudhomme, M.; Bourgaux, J.F.; Castells, A.; Pascussi, J.M.; Heriot, A.G.; Puisieux, A.; Davis, M.J.; Pannequin, J.; et al.
2019Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemiaBell, C.C.; Fennell, K.A.; Chan, Y.C.; Rambow, F.; Yeung, M.M.; Vassiliadis, D.; Lara, L.; Yeh, P.; Martelotto, L.G.; Rogiers, A.; Kremer, B.E.; Barbash, O.; Mohammad, H.P.; Johanson, T.M.; Burr, M.L.; Dhar, A.; Karpinich, N.; Tian, L.; Tyler, D.S.; MacPherson, L.; et al.
2021CDK4/6 inhibition promotes antitumor immunity through the induction of T-cell memoryLelliott, E.J.; Kong, I.Y.; Zethoven, M.; Ramsbottom, K.M.; Martelotto, L.G.; Meyran, D.; Zhu, J.J.; Costacurta, M.; Kirby, L.; Sandow, J.J.; Lim, L.; Dominguez, P.M.; Todorovski, I.; Haynes, N.M.; Beavis, P.A.; Neeson, P.J.; Hawkins, E.D.; McArthur, G.A.; Parish, I.A.; Johnstone, R.W.; et al.
2018Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapyMarini, K.D.; Croucher, D.R.; McCloy, R.A.; Vaghjiani, V.; Gonzalez-Rajal, A.; Hastings, J.F.; Chin, V.; Szczepny, A.; Kostyrko, K.; Marquez, C.; Samantha, W.; Jayasekara, N.; Alamgeer, M.; Boolell, V.; Han, J.Z.R.; Waugh, T.; Lee, H.C.; Oakes, S.R.; Kumar, B.; Harrison, C.A.; et al.