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https://hdl.handle.net/2440/60581
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Type: | Journal article |
Title: | Pallidotomy does not ameliorate abnormal intracortical inhibition in Parkinson's disease |
Author: | Sale, M. Nordstrom, M. Brophy, B. Thompson, P. |
Citation: | Journal of Clinical Neuroscience, 2010; 17(6):711-716 |
Publisher: | Churchill Livingstone |
Issue Date: | 2010 |
ISSN: | 0967-5868 1532-2653 |
Statement of Responsibility: | M.V. Sale, M.A. Nordstrom, B.P. Brophy and P.D. Thompson |
Abstract: | Motor cortex excitability was assessed in 12 patients with Parkinson's disease (PD) using transcranial magnetic stimulation. Patients were studied when mobile and medicated ("ON") and when immobile after medication withdrawal ("OFF"). Results were compared to eight age-matched and 11 young controls. Cortical excitability was assessed by measurement of resting motor threshold (RMT), intracortical inhibition and cortical silent period duration. In five patients, the studies included assessments following pallidotomy. Cortical excitability was abnormal in patients with PD with reduced RMT in "ON" and "OFF" states, and less effective intracortical inhibition. Pallidotomy did not affect cortical excitability in either "ON" or "OFF" states, indicating that enhanced motor cortex excitability in patients with PD is unaffected by pallidotomy despite clinical improvement in motor scores. |
Keywords: | Intracortical inhibition Motor cortex Pallidotomy Parkinson’s disease TMS |
Rights: | Copyright © 2009 Elsevier Ltd All rights reserved. |
DOI: | 10.1016/j.jocn.2009.09.038 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/623056/description#description |
Published version: | http://dx.doi.org/10.1016/j.jocn.2009.09.038 |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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