Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/61993
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | The response to repetitive stimulation of human motor cortex is influenced by the history of synaptic activity |
Author: | Todd, G. Ridding, M. |
Citation: | Restorative Neurology and Neuroscience, 2010; 28(4):459-467 |
Publisher: | IOS Press |
Issue Date: | 2010 |
ISSN: | 0922-6028 1878-3627 |
Statement of Responsibility: | G. Todd and M.C. Ridding |
Abstract: | Non-invasive brain stimulation techniques, such as repetitive transcranial magnetic stimulation (rTMS), can modify cortical excitability in a lasting fashion. The modification can be bi-directional in nature and holds considerable therapeutic promise for a number of neurological conditions. However, the effectiveness of these techniques is currently limited by large intra- and inter-subject variability in the response. A number of factors that contribute to response variability have now been identified, with one of the most important being the history of synaptic activity within the cortical region being targeted by stimulation. In this review we discuss what is currently known about the influence of behaviourally, or experimentally, induced changes in synaptic activity in the cortical (or interconnected) region being targeted by stimulation on the response to rTMS techniques. Understanding such influences is a critical step in the development of effective therapeutic paradigms employing such techniques. |
Keywords: | Motor Cortex Synapses Animals Humans Behavior Individuality Transcranial Magnetic Stimulation |
Rights: | © 2010 – IOS Press and the authors. All rights reserved. |
DOI: | 10.3233/RNN-2010-0565 |
Published version: | http://dx.doi.org/10.3233/rnn-2010-0565 |
Appears in Collections: | Aurora harvest 5 Obstetrics and Gynaecology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.