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https://hdl.handle.net/2440/63621
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Type: | Journal article |
Title: | Efficacy of lactobacillus GG in aboriginal children with acute diarrhoeal disease: A randomised clinical trial |
Author: | Ritchie, B. Brewster, D. Tran, C. Davidson, G. McNeil, Y. Butler, R. |
Citation: | Journal of Pediatric Gastroenterology and Nutrition, 2010; 50(6):619-624 |
Publisher: | Lippincott Williams & Wilkins |
Issue Date: | 2010 |
ISSN: | 0277-2116 1536-4801 |
Statement of Responsibility: | Brett K. Ritchie, David R. Brewster, Cuong D. Tran, Geoffrey P. Davidson, Yvette McNeil, Ross N. Butler |
Abstract: | <h4>Objective</h4>The effectiveness of probiotic therapy for acute rotavirus infectious diarrhoea in an indigenous setting with bacterial/parasitic diarrhoea is unclear. In the present study, we assessed the efficacy of probiotics in Australian Aboriginal children in the Northern Territory admitted to hospital with diarrhoeal disease.<h4>Patients and methods</h4>A randomised double-blind placebo-controlled study was conducted in Aboriginal children (ages 4 months-2 years), admitted to hospital with acute diarrhoeal disease (>3 loose stools per day). Children received either oral Lactobacillus GG (5 x 10(9) colony-forming units 3 times per day for 3 days; n = 33) or placebo (n = 31). Small intestinal functional capacity was assessed by the noninvasive 13C-sucrose breath test on days 1 and 4.<h4>Results</h4>Both groups showed mean improvement in the sucrose breath test after 4 days; however, there was no difference (mean, 95% confidence interval) between probiotic (2.9 [cumulative percentage of dose recovered at 90 minutes]; 1.7-4.2) and placebo (3.7; 2.3-5.2) groups. Probiotics did not change the duration of diarrhoea, total diarrhoea stools, or diarrhoea score compared with placebo. There was a significant (P < 0.05) difference in diarrhoea frequency on day 2 between probiotics (3.3 [loose stools]; 2.5-4.3) and placebo (4.7; 3.8-5.7) groups.<h4>Conclusions</h4>Lactobacillus GG did not appear to enhance short-term recovery following acute diarrhoeal illness in this setting. |
Keywords: | Aboriginal diarrhoeal probiotic. |
Rights: | (C) 2010 Lippincott Williams & Wilkins, Inc. |
DOI: | 10.1097/MPG.0b013e3181bbf53d |
Published version: | http://dx.doi.org/10.1097/mpg.0b013e3181bbf53d |
Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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