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https://hdl.handle.net/2440/65647
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Type: | Journal article |
Title: | Vitamin D₃ signalling to mast cells: A new regulatory axis |
Other Titles: | Vitamin D(3) signalling to mast cells: A new regulatory axis |
Author: | Yu, C. Fedoric, B. Anderson, P. Lopez, A. Grimbaldeston, M. |
Citation: | The International Journal of Biochemistry and Cell Biology, 2011; 43(1):41-46 |
Publisher: | Pergamon-Elsevier Science Ltd |
Issue Date: | 2011 |
ISSN: | 1357-2725 1878-5875 |
Statement of Responsibility: | Chunping Yu, Boris Fedoric, Paul H. Anderson, Angel F. Lopez, Michele A. Grimbaldeston |
Abstract: | Excessive sun exposure or high acute doses of ultraviolet (UV)-B radiation promote cutaneous inflammation and genetic mutations, both of which can ultimately contribute to skin carcinogenesis. A major mediator synthesized in the epidermis in response to UVB irradiation is the secosteroid hormone vitamin D3, and as such, considerable attention is now turning to the many physiologic processes that it regulates. Recent studies have uncovered an immunoregulatory interaction between vitamin D3 and dermal mast cells for optimal protection against pathogenic outcomes associated with chronic UVB irradiation of the skin. Most biological effects of vitamin D3, such as the regulation of transcription in target genes, occur when it binds to its nuclear receptor; however, some actions can also occur via a non-genomic signalling pathway. This review will focus on the relative importance of both pathways in the regulation of vitamin D3-mediated UVB protection and will highlight exciting recent findings that point to new research directions. |
Keywords: | Mast cells Vitamin D Immune regulation |
Rights: | Crown Copyright © 2010 Published by Elsevier Ltd. All rights reserved. |
DOI: | 10.1016/j.biocel.2010.10.011 |
Published version: | http://www.sciencedirect.com/science/article/pii/S1357272510003560 |
Appears in Collections: | Aurora harvest 5 Molecular and Biomedical Science publications |
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