Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/65734
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Auditory processing of sine tones before, during and after ECT in depressed patients by fMRI |
Author: | Christ, M. Michael, N. Hihn, H. Schuttke, A. Konrad, C. Baune, B. Jansen, A. Pfleiderer, B. |
Citation: | Journal of Neural Transmission, 2008; 115(8):1199-1211 |
Publisher: | Springer-Verlag Wien |
Issue Date: | 2008 |
ISSN: | 0300-9564 1435-1463 |
Statement of Responsibility: | Martin Christ, Nikolaus Michael, Hermina Hihn, Anne Schuüttke, Carsten Konrad, Bernhard T. Baune, Andreas Jansen, Bettina Pfleiderer |
Abstract: | Our goal was to assess treatment effects of electroconvulsive therapy (ECT) on acoustic processing in major depression. We hypothesized that (1) depression is related to functional alterations in auditory networks, and that (2) pre-treatment alterations in auditory networks are reversible through treatment with ECT. Acoustic perception of 20 severely depressed and 20 age and gender matched healthy controls was investigated by 3 T functional magnetic resonance imaging employing repeated stimulation by sine tones. Prior to ECT, depressed patients presented a multimodal recruitment of additional brain areas including regions of the secondary visual system (cuneus, lingualis) and the medial frontal cortex. During ECT, signal intensities were reduced compared to pre-ECT values and controls. Activation of several regions increased after ECT. Our data suggest that depression is accompanied by cortical dysfunction including impaired auditory processing of non-speech stimuli. This might be based on overall alterations of brain metabolism indicating functional impairment. |
Keywords: | Depression fMRI Auditory processing Tones ECT |
Rights: | © Springer-Verlag 2008 |
DOI: | 10.1007/s00702-008-0036-5 |
Published version: | http://dx.doi.org/10.1007/s00702-008-0036-5 |
Appears in Collections: | Aurora harvest 5 Psychiatry publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.