Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/65859
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Effects of adjunctive antidepressant therapy with quetiapine on clinical outcome, quality of sleep and daytime motor activity in patients with treatment-resistant depression |
Author: | Baune, B. Caliskan, S. Todder, D. |
Citation: | Human Psychopharmacology, 2007; 22(1):1-9 |
Publisher: | John Wiley & Sons Ltd |
Issue Date: | 2007 |
ISSN: | 0885-6222 1099-1077 |
Statement of Responsibility: | B. T. Baune, S. Caliskan and D. Todder |
Abstract: | <h4>Objective</h4>To investigate the effects of antidepressant therapy plus quetiapine on major depression, motor activity, daytime sleepiness and quality of sleep.<h4>Methods</h4>Patients (N = 27) with major depressive disorder received a standard antidepressant treatment (Venlafaxine, Escitalopram) plus flexible dose of quetiapine. Patients' depression was monitored with HAM-D-21, motor activity was continuously measured with actigraphy and sleep parameters with the Pittsburgh Sleep Quality Index (PSQI) over 4 weeks.<h4>Results</h4>Whereas depression, quality of sleep and daytime sleepiness showed a significant improvement over 4 weeks, change of daytime motor activity was significant only between the wash out period and the last 2 days of the study. Repeated measures of variance indicate an independent influence of quetiapine on improved depression, motor activity and sleep. While we found only a mild decrease of daytime sleepiness during the first week of treatment, the further decline of daytime sleepiness got significant after 2 weeks of treatment with quetiapine, even at high mean daily doses and despite the sedative effects of quetiapine.<h4>Conclusions</h4>Antidepressant treatment plus quetiapine is possibly a suitable treatment strategy to improve clinical depression, quality of sleep and motor activity. Future research is needed to understand the pharmacological interactions between antidepressants and quetiapine in major depression. |
Keywords: | quetiapine adjunctive therapy antidepressant sleep major depression motor activity |
Rights: | Copyright © 2007 John Wiley & Sons, Ltd. |
DOI: | 10.1002/hup.817 |
Published version: | http://dx.doi.org/10.1002/hup.817 |
Appears in Collections: | Aurora harvest Psychiatry publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.