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https://hdl.handle.net/2440/66046
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dc.contributor.author | Domschke, K. | - |
dc.contributor.author | Dannlowski, U. | - |
dc.contributor.author | Hohoff, C. | - |
dc.contributor.author | Ohrmann, P. | - |
dc.contributor.author | Bauer, J. | - |
dc.contributor.author | Kugel, H. | - |
dc.contributor.author | Zwanzger, P. | - |
dc.contributor.author | Heindel, W. | - |
dc.contributor.author | Deckert, J. | - |
dc.contributor.author | Arolt, V. | - |
dc.contributor.author | Suslow, T. | - |
dc.contributor.author | Baune, B. | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | European Neuropsychopharmacology, 2010; 20(5):301-309 | - |
dc.identifier.issn | 0924-977X | - |
dc.identifier.issn | 1873-7862 | - |
dc.identifier.uri | http://hdl.handle.net/2440/66046 | - |
dc.description.abstract | Neuropeptide Y (NPY) has been found to play a role in the pathomechanism of both anxiety and depression. Thus, NPY is a promising candidate in the investigation of the clinical phenotype of "anxious depression". Five NPY gene variants were investigated for an influence on antidepressant treatment response in a sample of 256 patients with depression. Additionally, NPY gene impact on amygdala activation during facial emotion processing was analyzed in a subsample of 35 depressed patients. Particularly in anxious depression, the less active NPY rs16147 -399C allele conferred slow response after 2weeks and failure to achieve remission after four weeks of treatment. The rs16147 C allele was further associated with stronger bilateral amygdala activation in response to threatening faces in an allele-dose fashion. The present results point towards a possible influence of functional NPY gene variation on antidepressant treatment response in anxious depression, potentially conveyed by altered emotional processing. | - |
dc.description.statementofresponsibility | Katharina Domschke, Udo Dannlowski, Christa Hohoff, Patricia Ohrmann, Jochen Bauer, Harald Kugel, Peter Zwanzger, Walter Heindel, Jürgen Deckert, Volker Arolt, Thomas Suslow, Bernhard T. Baune | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Science BV | - |
dc.rights | © 2009 Elsevier B.V. and ECNP. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.euroneuro.2009.09.006 | - |
dc.subject | Pharmacogenetics | - |
dc.subject | Imaging genetics | - |
dc.subject | Depression | - |
dc.subject | Anxiety | - |
dc.subject | NPY | - |
dc.title | Neuropeptide Y (NPY) gene: Impact on emotional processing and treatment response in anxious depression | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.euroneuro.2009.09.006 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Baune, B. [0000-0001-6548-426X] | - |
Appears in Collections: | Aurora harvest 5 Psychiatry publications |
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