Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/66156
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Type: | Journal article |
Title: | Exploring the immunoproteome for ovarian cancer biomarker discovery |
Author: | Martin, K. Ricciardelli, C. Hoffmann, P. Oehler, M. |
Citation: | International Journal of Molecular Sciences, 2011; 12(1):410-428 |
Publisher: | Molecular Diversity Preservation International (MDPI) AG. |
Issue Date: | 2011 |
ISSN: | 1422-0067 1422-0067 |
Statement of Responsibility: | Karina Martin, Carmela Ricciardelli, Peter Hoffmann and Martin K. Oehler |
Abstract: | Most scientific efforts towards early detection of ovarian cancer are commonly focused on the discovery of tumour-associated antigens (TAA). Autologous antibodies against TAA, however, may serve as more sensitive diagnostic markers. They circulate in the blood before TAA and are usually more abundant than the TAAs themselves as a result of amplification through the humoral immune response. Accumulating evidence also suggests that a humoral response already exists during malignant transformation when aberrant gene expression is translated into premalignant cellular changes. This article reviews the current knowledge about autoantibodies against TAA in ovarian cancer and presents current immunoproteomic approaches for their detection. |
Keywords: | ovarian cancer autoantibodies immunoproteomics |
Rights: | © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
DOI: | 10.3390/ijms12010410 |
Published version: | http://dx.doi.org/10.3390/ijms12010410 |
Appears in Collections: | Aurora harvest 5 Molecular and Biomedical Science publications |
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hdl_66156.pdf | Published version | 1.34 MB | Adobe PDF | View/Open |
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