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https://hdl.handle.net/2440/66186
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Type: | Journal article |
Title: | Larval midgut destruction in Drosophila: Not dependent on caspases but suppressed by the loss of autophagy |
Author: | Denton, D. Shravage, B. Simin, R. Baehrecke, E. Kumar, S. |
Citation: | Autophagy, 2010; 6(1):163-165 |
Publisher: | Landes Bioscience |
Issue Date: | 2010 |
ISSN: | 1554-8627 1554-8635 |
Statement of Responsibility: | Donna Denton, Bhupendra V. Shravage, Rachel Simin, Eric H. Baehrecke and Sharad Kumar |
Abstract: | While most programmed cell death (PCD) in animal development is reliant upon the caspase-dependent apoptotic pathway and subsequent cleavage of caspase substrates, we found that PCD in Drosophila larval midgut occurs normally in the absence of the main components of the apoptotic machinery. However, when some of the components of the autophagic machinery were disrupted, midgut destruction was severely delayed. These studies demonstrate that Drosophila midgut PCD is executed by a novel mechanism where caspases are apparently dispensable, but that requires autophagy. |
Keywords: | apoptosis caspases programmed cell death metamorphosis decay |
Rights: | © 2010 Landes Bioscience |
DOI: | 10.4161/auto.6.1.10601 |
Published version: | http://dx.doi.org/10.4161/auto.6.1.10601 |
Appears in Collections: | Aurora harvest 5 Molecular and Biomedical Science publications |
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