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https://hdl.handle.net/2440/66343
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dc.contributor.author | Grace, P. | - |
dc.contributor.author | Rolan, P. | - |
dc.contributor.author | Hutchinson, M. | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Brain, Behavior, and Immunity, 2011; 25(7):1322-1332 | - |
dc.identifier.issn | 0889-1591 | - |
dc.identifier.issn | 1090-2139 | - |
dc.identifier.uri | http://hdl.handle.net/2440/66343 | - |
dc.description.abstract | Recent evidence implicates an adaptive immune response in the central nervous system (CNS) mechanisms of neuropathic pain. This review identifies how neuropathic pain alters CNS immune privilege to facilitate T cell infiltration. Once in the CNS, T cells may interact with the local antigen presenting cells, microglia, via the major histocompatibility complex and the costimulatory molecules CD40 and B7. In this way, T cells may contribute to the maintenance of neuropathic pain through pro-inflammatory interactions with microglia and by facilitating the activation of astrocytes in the spinal dorsal horn. Based on the evidence presented in this review, we suggest that this bidirectional, pro-inflammatory system of neurons, glia and T cells in neuropathic pain should be renamed the pentapartite synapse, and identifies the latest member as a potential disease-modifying therapeutic target. | - |
dc.description.statementofresponsibility | Peter M. Grace, Paul E. Rolan and Mark R. Hutchinson | - |
dc.language.iso | en | - |
dc.publisher | Academic Press Inc | - |
dc.rights | Copyright © 2011 Elsevier Inc. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.bbi.2011.04.003 | - |
dc.subject | Allodynia | - |
dc.subject | Central nervous system | - |
dc.subject | Glia | - |
dc.subject | Neuropathic pain | - |
dc.subject | T cell | - |
dc.subject | Immunological synapse | - |
dc.title | Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.bbi.2011.04.003 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Grace, P. [0000-0002-8999-1220] | - |
dc.identifier.orcid | Hutchinson, M. [0000-0003-2154-5950] | - |
Appears in Collections: | Aurora harvest Pharmacology publications |
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