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https://hdl.handle.net/2440/66647
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Type: | Journal article |
Title: | Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions |
Author: | Yang, B. Kumar, S. |
Citation: | Cell Death and Differentiation, 2009; 17(1):68-77 |
Publisher: | Nature Publishing Group |
Issue Date: | 2009 |
ISSN: | 1350-9047 1476-5403 |
Statement of Responsibility: | B Yang and S Kumar |
Abstract: | The Nedd4 (neural precursor cell-expressed developmentally downregulated gene 4) family of ubiquitin ligases (E3s) is characterized by a distinct modular domain architecture, with each member consisting of a C2 domain, 2-4 WW domains, and a HECT-type ligase domain. Of the nine mammalian members of this family, Nedd4 and its close relative, Nedd4-2, represent the ancestral ligases with strong similarity to the yeast, Rsp5. In Saccharomyces cerevisiae Rsp5 has a key role in regulating the trafficking, sorting, and degradation of a large number of proteins in multiple cellular compartments. However, in mammals the Nedd4 family members, including Nedd4 and Nedd4-2, appear to have distinct functions, thereby suggesting that these E3s target specific proteins for ubiquitylation. In this article we focus on the biology and emerging functions of Nedd4 and Nedd4-2, and review recent in vivo studies on these E3s. |
Keywords: | ubiquitylation endocytosis trafficking receptor signaling |
Rights: | Copyright 2010 Macmillan Publishers Limited |
DOI: | 10.1038/cdd.2009.84 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/508086 http://purl.org/au-research/grants/arc/DP0880571 http://purl.org/au-research/grants/arc/DP0880571 |
Published version: | http://dx.doi.org/10.1038/cdd.2009.84 |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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