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Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/66904
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dc.contributor.authorBeyer, M.-
dc.contributor.authorSadlon, T.-
dc.contributor.authorBarry, S.-
dc.date.issued2011-
dc.identifier.citationNature Immunology, 2011; 12(9):898-907-
dc.identifier.issn1529-2908-
dc.identifier.issn1529-2916-
dc.identifier.urihttp://hdl.handle.net/2440/66904-
dc.description.abstractRegulatory T cells (T(reg) cells) are essential for self-tolerance and immune homeostasis. Lack of effector T cell (T(eff) cell) function and gain of suppressive activity by T(reg) cells are dependent on the transcriptional program induced by Foxp3. Here we report that repression of SATB1, a genome organizer that regulates chromatin structure and gene expression, was crucial for the phenotype and function of T(reg) cells. Foxp3, acting as a transcriptional repressor, directly suppressed the SATB1 locus and indirectly suppressed it through the induction of microRNAs that bound the SATB1 3' untranslated region. Release of SATB1 from the control of Foxp3 in T(reg) cells caused loss of suppressive function, establishment of transcriptional T(eff) cell programs and induction of T(eff) cell cytokines. Our data support the proposal that inhibition of SATB1-mediated modulation of global chromatin remodeling is pivotal for maintaining T(reg) cell functionality.-
dc.description.statementofresponsibilityMarc Beyer... Timothy Sadlon...Simon C Barry... et al.-
dc.language.isoen-
dc.publisherNature Publishing Group-
dc.rights© 2011 Nature America, Inc. All rights reserved.-
dc.source.urihttp://dx.doi.org/10.1038/ni.2084-
dc.subjectAnimals-
dc.subjectMice, Inbred C57BL-
dc.subjectMice, Knockout-
dc.subjectHumans-
dc.subjectMice-
dc.subjectLentivirus-
dc.subjectMatrix Attachment Region Binding Proteins-
dc.subjectMicroRNAs-
dc.subjectRNA, Small Interfering-
dc.subject3' Untranslated Regions-
dc.subjectFlow Cytometry-
dc.subjectGene Expression Profiling-
dc.subjectTransduction, Genetic-
dc.subjectReverse Transcriptase Polymerase Chain Reaction-
dc.subjectLymphocyte Activation-
dc.subjectCell Differentiation-
dc.subjectChromatin Assembly and Disassembly-
dc.subjectSelf Tolerance-
dc.subjectGene Expression Regulation-
dc.subjectRNA Interference-
dc.subjectGenome, Human-
dc.subjectT-Lymphocytes, Regulatory-
dc.subjectForkhead Transcription Factors-
dc.subjectGenome-Wide Association Study-
dc.titleRepression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation-
dc.typeJournal article-
dc.identifier.doi10.1038/ni.2084-
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/399123-
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/565314-
pubs.publication-statusPublished-
dc.identifier.orcidSadlon, T. [0000-0002-4821-2462]-
dc.identifier.orcidBarry, S. [0000-0002-0597-7609]-
Appears in Collections:Aurora harvest
Microbiology and Immunology publications

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