Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/66970
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Lower esophageal sphincter relaxation is impaired in older patients with dysphagia |
Author: | Besanko, L. Burgstad, C. Mountifield, R. Andrews, J. Heddle, R. Checklin, H. Fraser, R. |
Citation: | World Journal of Gastroenterology, 2011; 17(10):1326-1331 |
Publisher: | W J G Press |
Issue Date: | 2011 |
ISSN: | 1007-9327 2219-2840 |
Statement of Responsibility: | Laura K Besanko, Carly M Burgstad, Reme Mountifield, Jane M Andrews, Richard Heddle, Helen Checklin, Robert JL Fraser |
Abstract: | AIM: To characterize the effects of age on the mechanisms underlying the common condition of esophageal dysphagia in older patients, using detailed manometric analysis. METHODS: A retrospective case-control audit was performed on 19 patients aged ≥ 80 years (mean age 85 ± 0.7 year) who underwent a manometric study for dysphagia (2004-2009). Data were compared with 19 younger dysphagic patients (32 ± 1.7 years). Detailed manometric analysis performed prospectively included basal lower esophageal sphincter pressure (BLESP), pre-swallow and nadir LESP, esophageal body pressures and peristaltic duration, during water swallows (5 mL) in right lateral (RL) and upright (UR) postures and with solids. Data are mean ± SE; a P-value < 0.05 was considered significant. RESULTS: Elderly dysphagic patients had higher BLESP than younger patients (23.4 ± 3.8 vs 14.9 ± 1.2 mmHg; P < 0.05). Pre-swallow LESP was elevated in the elderly in both postures (RL: 1 and 4 s P = 0.019 and P = 0.05; UR: P < 0.05 and P = 0.05) and solids (P < 0.01). In older patients, LES nadir pressure was higher with liquids (RL: 2.3 ± 0.6 mmHg vs 0.7 ± 0.6 mmHg, P < 0.05; UR: 3.5 ± 0.9 mmHg vs 1.6 ± 0.5 mmHg, P = 0.01) with shorter relaxation after solids (7.9 ± 1.5 s vs 9.7 ± 0.4 s, P = 0.05). No age-related differences were seen in esophageal body pressures or peristalsis duration. CONCLUSION: Basal LES pressure is elevated and swallow-induced relaxation impaired in elderly dysphagic patients. Its contribution to dysphagia and the effects of healthy ageing require further investigation. |
Keywords: | Dysphagia Elderly Esophageal Motility Lower Esophageal Sphincter Aging |
Rights: | Copyright ©2011 Baishideng Publishing Group Co., Limited. All rights reserved. |
DOI: | 10.3748/wjg.v17.i10.1326 |
Published version: | http://dx.doi.org/10.3748/wjg.v17.i10.1326 |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.