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https://hdl.handle.net/2440/67168
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dc.contributor.author | Turner, R. | - |
dc.contributor.author | Helps, S. | - |
dc.contributor.author | Thornton, E. | - |
dc.contributor.author | Vink, R. | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Brain Research, 2011; 1393:84-90 | - |
dc.identifier.issn | 0006-8993 | - |
dc.identifier.issn | 1872-6240 | - |
dc.identifier.uri | http://hdl.handle.net/2440/67168 | - |
dc.description.abstract | Previous studies have suggested that substance P (SP) plays a critical role in the development of brain oedema and functional deficits following traumatic brain injury and that SP receptor antagonism may improve outcome. No studies have described such a role in ischemic stroke. The present study characterized the effects of the NK1 tachykinin receptor antagonist, n-acetyl-L-tryptophan (NAT), on blood-brain barrier (BBB) breakdown, oedema formation, infarct volume and functional outcome following reversible ischemic stroke in rats. Ischemia was induced using a reversible thread model of middle cerebral artery occlusion where occlusion was maintained for 2 h before reperfusion. Animals received either NAT or equal volume saline vehicle intravenously at 2 h post-reperfusion. Ischaemic stroke resulted in increased perivascular SP immunoreactivity at 24 h. Administration of NAT significantly reduced oedema formation and BBB permeability at 24 h post-ischemia and significantly improved functional outcome as assessed over 7 days. There was no effect on infarct volume. We conclude that inhibition of SP activity with a NK1 tachykinin receptor antagonist is effective in reducing cerebral oedema, BBB permeability and functional deficits following reversible ischemia and may therefore represent a novel therapeutic approach to the treatment of ischaemic stroke. | - |
dc.description.statementofresponsibility | Renée J. Turner, Stephen C. Helps, Emma Thornton and Robert Vink | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Science Bv | - |
dc.rights | © 2011 Elsevier B.V. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.brainres.2011.03.066 | - |
dc.subject | Ischaemic stroke | - |
dc.subject | NK1 tachykinin receptor antagonist | - |
dc.subject | Oedema | - |
dc.subject | Neuropeptides | - |
dc.subject | Neurogenic inflammation | - |
dc.title | A substance P antagonist improves outcome when administered 4 h after onset of ischaemic stroke | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.brainres.2011.03.066 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Turner, R. [0000-0003-4278-8302] | - |
dc.identifier.orcid | Vink, R. [0000-0002-4885-0667] | - |
Appears in Collections: | Aurora harvest 5 Medical Sciences publications |
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