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https://hdl.handle.net/2440/67169
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Type: | Journal article |
Title: | The differential diagnosis of localised amelanotic limbal lesions: a review of 162 consecutive excisions |
Author: | Rudkin, A. Dodd, T. Muecke, J. |
Citation: | British Journal of Ophthalmology, 2011; 95(3):350-354 |
Publisher: | British Med Journal Publ Group |
Issue Date: | 2011 |
ISSN: | 0007-1161 1468-2079 |
Statement of Responsibility: | Adam K Rudkin, Tom Dodd, James S Muecke |
Abstract: | Aims: To report the distribution of histopathological diagnoses in patients who underwent excision of localised limbal lesions that were clinically suspected to be squamous neoplasia (intra-epithelial neoplasia or squamous cell carcinoma). Methods: 162 consecutive patients of a single ocular oncologist underwent an excisional biopsy between 1998 and 2009 for suspected squamous neoplasia. Histopathological reports were retrospectively reviewed. Results: The population comprised 122 males and 40 females. The mean age was 63.4±15.8 (range: 27–90). 138 (85.2%) lesions were identified as intraepithelial neoplasia (CIN), of which 34 (21.0%) were CIN I, 32 (19.8%) were CIN II and 72 (44.4%) were CIN III or squamous cell carcinoma in situ. In seven (4.3%) cases, the lesion was invasive squamous cell carcinoma. In two (1.2%) cases, the lesion was amelanotic malignant melanoma. In 16 (9.9%) cases, histopathology revealed a benign entity including lesions described as squamous papilloma, solar elastosis and epithelial hyperplasia, keratosis or reactive atypia. Conclusions: In this population, for an experienced ocular oncologist, the misdiagnosis of localised limbal squamous neoplasia occurred in 10.5% of cases, with 5.5% of cases being malignant. This study highlights the importance of acquiring a clinical diagnosis before administering a topical chemotherapeutic agent. |
Keywords: | Humans Melanoma, Amelanotic Carcinoma in Situ Carcinoma, Squamous Cell Conjunctival Neoplasms Precancerous Conditions Diagnosis, Differential Retrospective Studies Adult Aged Aged, 80 and over Middle Aged Female Male |
Rights: | Copyright status unknown |
DOI: | 10.1136/bjo.2009.172189 |
Published version: | http://dx.doi.org/10.1136/bjo.2009.172189 |
Appears in Collections: | Aurora harvest 5 Opthalmology & Visual Sciences publications |
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