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https://hdl.handle.net/2440/68234
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Type: | Journal article |
Title: | An integrative assessment of brain and body function 'at rest' in panic disorder: A combined quantitative EEG/autonomic function study |
Author: | Wise, V. McFarlane, A. Clark, C. Battersby, M. |
Citation: | International Journal of Psychophysiology, 2011; 79(2):155-165 |
Publisher: | Elsevier Science BV |
Issue Date: | 2011 |
ISSN: | 0167-8760 1872-7697 |
Statement of Responsibility: | Vikki Wise, Alexander C. McFarlane, C. Richard Clark, Malcolm Battersby |
Abstract: | We conducted a quantitative electroencephalographic (QEEG) and autonomic assessment of panic disorder (PD). The study samples comprised 52 individuals meeting DSM-IV criteria for PD (with or without agoraphobia) and 104 age-, gender-, and handedness-matched controls. EEG data were acquired from 16 scalp sites during resting eyes-open (REO) and eyes-closed (REC) conditions, and spectral power was assessed within 4 frequency bands: theta, alpha-1, alpha-2, and beta. The main findings were an overall reduction of spectral power in PD, compared to controls (Group main effect, p=.011), which was most apparent during REC (Group Condition interaction, p=.014), and within the alpha-1 frequency band (8-11 Hz; Group Band interaction, p=.014). Alpha-1 desynchronization occurs in response to increases in non-specific information processing, and aspects of attention such as alertness. Other findings were region-specific alterations of spectral power at frontal and temporal scalp sites, including a frontal alpha-1 asymmetry (R<L power) during REC in patients, but not controls. Findings for concomitantly-recorded autonomic measures included elevated heart rate, lower heart rate variability, and reduced rate of decrement of skin conductance level in patients, compared to controls. Finally, analyses examining the within-subjects relationship of central and peripheral function measures showed a differential pattern in patients and controls. Possible causes of these disturbances of brain and body function 'at rest', such as patients' ongoing automatic and strategic engagement with multiple disorder-related threat cues, including somatic variability and the testing environment, are discussed. |
Keywords: | QEEG Alpha Autonomic Integrative Panic Disorder |
Rights: | Copyright © 2010 Elsevier B.V. Published by Elsevier B.V. All rights reserved. |
DOI: | 10.1016/j.ijpsycho.2010.10.002 |
Published version: | http://dx.doi.org/10.1016/j.ijpsycho.2010.10.002 |
Appears in Collections: | Aurora harvest Public Health publications |
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