Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/68305
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Pill content, dose and resulting plasma concentrations of 3,4-methylendioxymethamphetamine (MDMA) in recreational 'ecstasy' users |
Author: | Morefield, K. Keane, M. Felgate, P. White, J. Irvine, R. |
Citation: | Addiction, 2011; 106(7):1293-1300 |
Publisher: | Blackwell Publishing Ltd |
Issue Date: | 2011 |
ISSN: | 0965-2140 1360-0443 |
Statement of Responsibility: | Kate M. Morefield, Michael Keane, Peter Felgate, Jason M. White & Rodney J. Irvine |
Abstract: | Aims: To improve our understanding of the pharmacology of 'ecstasy' in recreational environments; in particular, to describe the composition of ecstasy pills, patterns of ecstasy use and the relationship between dose of 3,4-methylendioxymethamphetamine (MDMA) and resulting plasma concentrations. Design, setting and participants: A naturalistic observational study of 56 experienced 'ecstasy' users in recreational settings in Australia. Measurements: Drug use patterns (number of pills consumed, other drugs consumed). drug content of pills and resultant plasma concentrations of MDMA and related drugs were assessed by gas chromatography/mass spectrometry (GC/MS). Findings: Ecstasy pills generally contained MDMA, but this was often combined with other drugs such as 3,4-methylendioxyethylamphetamine (MDEA) and methamphetamine. The dose of MDMA per pill ranged from 0 to 245 mg and users consumed from one-half to five pills, with the total dose consumed ranging up to 280 mg. Plasma concentrations of MDMA increased with number of pills consumed and cumulative MDMA dose. Use of larger numbers of pills was associated with extended exposure to the drug. Conclusions: MDMA is the major active drug in ecstasy pills, but there is a high degree of variation in doses. Use of multiple pills over the course of one session is common and results in a sustained increase in MDMA plasma concentrations over a number of hours. This is likely to lead to a much greater exposure of the brain to MDMA than would be predicted from controlled single-dose pharmacokinetic studies. |
Keywords: | 3,4-methylenedioxymethamphetamine drug concentrations drug dose ecstasy MDMA pill content. |
Rights: | © 2011 The Authors, Addiction © 2011 Society for the Study of Addiction |
DOI: | 10.1111/j.1360-0443.2011.03399.x |
Published version: | http://dx.doi.org/10.1111/j.1360-0443.2011.03399.x |
Appears in Collections: | Aurora harvest Pharmacology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.