Total synthesis of (+)-A83586C, (+)- kettapeptin and (+)-azinothricin: powerful new inhibitors of β-catenin/TCF4- and E2F-mediated gene transcription

Hale, K.; Manaviazar, S.; George, J.

Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/68553

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DC Field	Value	Language
dc.contributor.author	Hale, K.	-
dc.contributor.author	Manaviazar, S.	-
dc.contributor.author	George, J.	-
dc.date.issued	2010	-
dc.identifier.citation	Chemical Communications, 2010; 46(23):4021-4042	-
dc.identifier.issn	1359-7345	-
dc.identifier.issn	1364-548X	-
dc.identifier.uri	http://hdl.handle.net/2440/68553	-
dc.description.abstract	Herein we describe our asymmetric total syntheses of (+)-A83586C, (+)-kettapeptin and (+)-azinothricin. We also demonstrate that molecules of this class powerfully inhibit β-catenin/TCF4- and E2F-mediated gene transcription within malignant human colon cancer cells at low drug concentrations.	-
dc.description.statementofresponsibility	Karl J. Hale, Soraya Manaviazar and Jonathan George	-
dc.language.iso	en	-
dc.publisher	Royal Soc Chemistry	-
dc.rights	This journal is copyright The Royal Society of Chemistry 2010	-
dc.source.uri	http://dx.doi.org/10.1039/c000603c	-
dc.subject	Cell Line, Tumor	-
dc.subject	Humans	-
dc.subject	Colonic Neoplasms	-
dc.subject	Depsipeptides	-
dc.subject	Peptides	-
dc.subject	Transcription Factors	-
dc.subject	Transcription, Genetic	-
dc.subject	E2F Transcription Factors	-
dc.subject	beta Catenin	-
dc.subject	Basic Helix-Loop-Helix Leucine Zipper Transcription Factors	-
dc.subject	Transcription Factor 4	-
dc.title	Total synthesis of (+)-A83586C, (+)- kettapeptin and (+)-azinothricin: powerful new inhibitors of β-catenin/TCF4- and E2F-mediated gene transcription	-
dc.title.alternative	Total synthesis of (+) - A83586C, (+)- kettapeptin and (+)- azinothricin: powerful new inhibitors of beta-catenin/TCF4- and E2F-mediated gene transcription	-
dc.type	Journal article	-
dc.identifier.doi	10.1039/C000603C	-
pubs.publication-status	Published	-
dc.identifier.orcid	George, J. [0000-0002-7330-2160]	-
Appears in Collections:	Aurora harvest Chemistry publications

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