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https://hdl.handle.net/2440/68585
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Type: | Journal article |
Title: | An unusual kynurenine-containing opioid tetrapeptide from the skin gland secretion of the Australian red tree frog Litoria rubella. Sequence determination by electrospray mass spectrometry |
Author: | Ellis-Steinborner, S. Scanlon, D. Musgrave, I. Tran, T. Hack, S. Wang, T. Abell, A. Tyler, M. Bowie, J. |
Citation: | Rapid Communications in Mass Spectrometry, 2011; 25(12):1735-1740 |
Publisher: | John Wiley & Sons Ltd |
Issue Date: | 2011 |
ISSN: | 0951-4198 1097-0231 |
Statement of Responsibility: | Simon T. Ellis‐Steinborner, Denis Scanlon, Ian F. Musgrave, T. T. Nha Tran, Sandra Hack, Tianfang Wang, Andrew D. Abell, Michael J. Tyler and John H. Bowie |
Abstract: | The Kyn-containing peptide FP-Kyn-L(NH(2)) is an unusual minor component of the skin peptide profile of the Australian red tree frog Litoria rubella collected from an area within a 20 kilometre radius of Alice Springs in central Australia. The structure was determined by electrospray mass spectrometry and synthesis. The major component of the skin secretion is the analogous tryptophyllin peptide FPWL(NH(2)). Both peptides show opioid activity at 10(-7) M, and are likely to act via the μ opioid receptor. |
Keywords: | Skin Animals Anura Kynurenine Oligopeptides Receptors, Opioid Analgesics, Opioid Spectrometry, Mass, Electrospray Ionization Sequence Analysis, Protein Australia |
Rights: | Copyright © 2011 John Wiley & Sons, Ltd. |
DOI: | 10.1002/rcm.5041 |
Grant ID: | ARC |
Published version: | http://dx.doi.org/10.1002/rcm.5041 |
Appears in Collections: | Aurora harvest IPAS publications |
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