Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/68929
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Oscillation of mitogen-activated protein kinases in response to endoplasmic reticulum stress |
Author: | Zhang, H. Zhao, Y. Tian, T. Paton, A. Paton, J. Kitamura, M. |
Citation: | Analytical Biochemistry, 2011; 417(2):292-294 |
Publisher: | Academic Press Inc Elsevier Science |
Issue Date: | 2011 |
ISSN: | 0003-2697 1096-0309 |
Statement of Responsibility: | Hui Zhang, Yang Zhao, Tian Tian, Adrienne W. Paton, James C. Paton, Masanori Kitamura |
Abstract: | Periodic patterns of biochemical systems determine the function, behavior, and fate of eukaryotic cells. The cascades of mitogen-activated protein (MAP) kinases play crucial roles in a diverse range of cell function, and recent reports indicate that oscillation of extracellular signal-regulated kinase (ERK) activity is observed following stimulation by some growth factors. In the current report, we provide evidence that ERK and c-Jun N-terminal kinase, but not p38 MAP kinase, are activated periodically in response to endoplasmic reticulum stress. When activity of MAP kinases is evaluated, their oscillatory property should be considered carefully, especially under stress conditions. |
Keywords: | MAP kinase ERK JNK Subtilase cytotoxin ER stress Oscillation |
Rights: | Copyright © 2011 Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.ab.2011.06.025 |
Published version: | http://dx.doi.org/10.1016/j.ab.2011.06.025 |
Appears in Collections: | Aurora harvest 5 Molecular and Biomedical Science publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.