Adelaide Research & Scholarship
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https://hdl.handle.net/2440/6959
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| Type: | Journal article |
| Title: | Use of high-performance liquid chromatography to study the pharmacokinetics of colistin sulfate in rats following intravenous administration |
| Author: | Li, J. Milne, R. Nation, R. Turnidge, J. Smeaton, T. Coulthard, K. |
| Citation: | Antimicrobial Agents and Chemotherapy, 2003; 47(5):1766-1770 |
| Publisher: | Amer Soc Microbiology |
| Issue Date: | 2003 |
| ISSN: | 0066-4804 1098-6596 |
| Abstract: | The pharmacokinetics of colistin was investigated using specific high-performance liquid chromatography (HPLC) to measure the concentrations of colistin and colistin A and B in plasma and urine in five rats after administration of an intravenous bolus of 1 mg of colistin sulfate/kg of body weight. There were differences in the pharmacokinetic behaviors of unbound colistin A and B. This is the first report of the use of HPLC to study the pharmacokinetics of colistin and its two major components. |
| Keywords: | Animals Rats Rats, Sprague-Dawley Colistin Anti-Bacterial Agents Metabolic Clearance Rate Chromatography, High Pressure Liquid Injections, Intravenous Protein Binding Male |
| DOI: | 10.1128/AAC.47.5.1766-1770.2003 |
| Published version: | http://dx.doi.org/10.1128/aac.47.5.1766-1770.2003 |
| Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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