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Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/7026
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dc.contributor.authorFriderici, K.-
dc.contributor.authorCavanagh, K.-
dc.contributor.authorLeipprandt, J.-
dc.contributor.authorTraviss, C.-
dc.contributor.authorAnson, D.-
dc.contributor.authorHopwood, J.-
dc.contributor.authorJones, M.-
dc.date.issued1995-
dc.identifier.citationBiochimica et Biophysica Acta: international journal of biochemistry and biophysics, 1995; 1271(2-3):369-373-
dc.identifier.issn0006-3002-
dc.identifier.issn1878-2434-
dc.identifier.urihttp://hdl.handle.net/2440/7026-
dc.description.abstractMucopolysaccharidosis IIID results from the deficiency of N-acetylglucosamine 6-sulfatase activity. A Nubian goat with this lysosomal storage disease has been identified. As a first step in developing this animal model for testing treatment methods, we cloned and sequenced the caprine N-acetylglucosamine 6-sulfatase cDNA coding region. Overall there is 88% nucleotide homology between the goat and human sequence and 94% homology of the deduced amino acid sequence. The human and two ruminant species differ by the presence of an imperfect trinucleotide (CCG) repeat in the ruminant signal sequence.-
dc.language.isoen-
dc.publisherElsevier/North Holland-
dc.source.urihttp://dx.doi.org/10.1016/0925-4439(95)00054-8-
dc.subjectAnimals-
dc.subjectGoats-
dc.subjectMucopolysaccharidosis III-
dc.subjectSulfatases-
dc.subjectDNA, Complementary-
dc.subjectCloning, Molecular-
dc.subjectAmino Acid Sequence-
dc.subjectBase Sequence-
dc.subjectSequence Homology, Amino Acid-
dc.subjectSequence Homology, Nucleic Acid-
dc.subjectMolecular Sequence Data-
dc.titleCloning and sequence analysis of caprine N-acetylglucosamine 6-sulfatase cDNA-
dc.typeJournal article-
dc.identifier.doi10.1016/0925-4439(95)00054-8-
pubs.publication-statusPublished-
Appears in Collections:Aurora harvest 5
Paediatrics publications

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