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https://hdl.handle.net/2440/7107
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DC Field | Value | Language |
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dc.contributor.author | Macardle, P. | - |
dc.contributor.author | Chen, Z. | - |
dc.contributor.author | Shih, C. | - |
dc.contributor.author | Huang, C. | - |
dc.contributor.author | Weedon, H. | - |
dc.contributor.author | Sun, Q. | - |
dc.contributor.author | Lopez, A. | - |
dc.contributor.author | Zola, H. | - |
dc.date.issued | 1996 | - |
dc.identifier.citation | Cellular Immunology, 1996; 168(1):59-68 | - |
dc.identifier.issn | 0008-8749 | - |
dc.identifier.issn | 1090-2163 | - |
dc.identifier.uri | http://hdl.handle.net/2440/7107 | - |
dc.description.abstract | Human leucocytes from peripheral blood and tonsil were examined for the presence of the IL-3 receptor using monoclonal antibodies directed to epitopes of the alpha and beta chains of the receptor. We found that the beta chain, common to IL-3, IL-5, and GM-CSF, was either present at low levels or not detected on the majority of peripheral blood and tonsil B lymphocytes, while the alpha chain showed a distinct but restricted distribution. In peripheral blood the IL-3R alpha chain was limited to a subpopulation of peripheral B lymphocytes and a population of cells which lack lineage-specific markers. Dimly staining cells were identified as B lymphocytes as they coexpressed CD19, CD20, CD22, CD24, and HLA-DR. A brightly staining population lacks T and B lymphocyte, NK specific, and macrophage lineage markers but expresses CD9, CD45RO, CD26, and, in a proportion of cells, CD36 and CD60. This population remains unclassified. In tonsil tissue IL-3R alpha chain expression was strongest on B lymphocytes present in the T cell rich areas of tonsillar tissue. The IL-3R alpha bearing B tonsil cells included cells in both CD23 and IgD positive and negative populations. The phenotype of the IL-3R alpha positive B cells defines them as a population of B lymphocytes distinct from previously characterized cells in the lymphoid architecture. Lymphoblastoid cell lines with a corresponding phenotype were also identified. | - |
dc.description.statementofresponsibility | P.J. Macardle, Z. Chen, C-Y. Shih, C-M. Huang, H. Weedon, Q. Sun, A.F. Lopez, H. Zola | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS | - |
dc.source.uri | http://dx.doi.org/10.1006/cimm.1996.0049 | - |
dc.subject | B-Lymphocytes | - |
dc.subject | Leukocytes, Mononuclear | - |
dc.subject | Cell Line | - |
dc.subject | Humans | - |
dc.subject | Receptors, Interleukin-3 | - |
dc.subject | Antigens, CD | - |
dc.subject | Cell Separation | - |
dc.subject | Lymphocyte Activation | - |
dc.subject | Child | - |
dc.subject | Child, Preschool | - |
dc.subject | Palatine Tonsil | - |
dc.title | Characterization of human leucocytes bearing the IL-3 receptor | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1006/cimm.1996.0049 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Lopez, A. [0000-0001-7430-0135] | - |
Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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