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https://hdl.handle.net/2440/7108
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Type: | Journal article |
Title: | Changes in CD44 expression during B cell differentiation in the human tonsil |
Author: | Kremmidiotis, G. Zola, H. |
Citation: | Cellular Immunology, 1995; 161(2):147-157 |
Publisher: | Academic Press |
Issue Date: | 1995 |
ISSN: | 0008-8749 1090-2163 |
Abstract: | CD44 is a widely distributed cell surface glycoprotein that has been implicated in a number of cellular adhesion processes and signal transduction events. These functional capabilities qualify CD44 as a potential mediator of contact-signaling events underlying the process of antigen-dependent B cell differentiation in secondary lymphoid tissues. We postulated that changes in the expression of CD44 during B cell differentiation reflect the cells' changing requirements for this receptor. It has been reported that germinal center B cells are low to negative for CD44 expression, implying that the receptor is lost upon activation. Correlation of the expression of CD44 with surface immunoglobulin and a number of B cell differentiation markers revealed a trimodal expression pattern. High levels of CD44 are expressed on resting IgD+/IgM+ cells. The receptor is still expressed at the early activation stage defined by the expression of CD23. At the early blast stage, when the blast marker CD38 appears on the cell surface and IgD and CD23 disappear, CD44 is downregulated. The majority of CD38+/IgM+ blasts and CD38+/Ig- centroblasts are CD44 low/negative. The receptor is re-upregulated at the point of transition from the centroblast to the centrocyte level. Centrocytes expressing IgG or IgA comprise CD44high and CD44low fractions. IgG+ or IgA+ cells at the postgerminal center stage express high levels of CD44. The functional implications of this expression pattern are discussed. |
Keywords: | B-Lymphocytes Lymphocyte Subsets Humans ADP-ribosyl Cyclase Carrier Proteins Membrane Glycoproteins Receptors, Lymphocyte Homing Receptors, Cell Surface Antigens, Differentiation Antigens, CD Flow Cytometry Lymphocyte Activation Cell Differentiation Palatine Tonsil Hyaluronan Receptors ADP-ribosyl Cyclase 1 |
DOI: | 10.1006/cimm.1995.1021 |
Published version: | http://dx.doi.org/10.1006/cimm.1995.1021 |
Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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